High cost of cancer care in the U.S. doesn’t reduce mortality rates
news.yale.edu
news.yale.edu
But for regular people, it's pretty much not a thing. It also made me wonder: How much more would it cost our health-care system, if everyone took advantage of things like annual checkups, or going through those extensive screens/tests that a lot of American patients go through. I guess the fear of malpractice lawsuits, higher insurance rates, or whatever make the medical centers in US a bit more incentivized to catch anything at all.
But AFAIK, we don't have any higher mortality rate here than those living in the US. Earlier this year I went to the doctor, because I was feeling a bit lethargic - turned out I had severe vitamin D deficiency. But other than that, it must be 7-8 years since I talked with a doctor.
(But credit where credit is due - the US seems like an excellent option IF you really need to get treated for certain cancers. It's not like we have "death panels" or awful long wait time here, but I know patients that have gone to the US to get treatment - on their own bill - for cancers that were deemed too advanced for treatment, here in Norway.)
The annual check up is something that's been advocated a long time, 50s at least, and predates the obesity epidemic.
The annual checkup is a symptom of a therapeutic view of health care, a view which cannot be divorced from modernism. The body is a machine which must be oiled and greased, frequently submitted to tests and expert investigation, so it can be tuned perfectly, just like a car, like a machine.
This really was _the_ obsession in post war America: that all human activity (really, all of it), needed to be mediated by technology. This included personal transportation, education, cooking, ... and also maintaining our health.
And that is where we are now; a chronically medicated population and a bureaucracy optimized to propagate this state of affairs. The annual checkup fits perfectly in this mindset.
Sports on the other hand do take a lot of time.
Plus I think they were probably talking about how all of those options are vastly more expensive than living on Raman and peanut butter sandwiches, especially once you count for prep time and power costs.
The checkup also isn’t a battery of tests unless you are at an age or condition for that. For a healthy 20 something that goes it’s basically the doctor checking your blood pressure and asking if anything has changed.
This research was about just cancer detection/treatment, but it's worrying that once they only mention correcting for smoking rates (umm duh, that's the least you need to do)... but then they don't mention weight... so weird?
The checkup is non-intrusive and for presumably healthy people consists of a physical, basic blood tests (glucose and some metabolic indicators + infection markers) and a blood pressure check. As an example, it's way cheaper to find out you have pre-diabetes this way, than to go to the doctor with symptoms when you have full on diabetes. This is mainly the reason why insurances pay for these in full, as they're part of 'preventive care'.
> How much more would it cost our health-care system, if everyone took advantage of
Annual checkups are definitely not the reason healthcare costs are sky-high in the US.
Is it? Or is it something that just seems obvious?
For these two, the data is very good that we're doing them too early.
The US is outstanding at taking money from sick people, just not any better at getting them well.
This sounds like the right way to go, but I want you to understand this is exactly what people mean when they say “death panels”.
You don't get annual bloodwork performed? Does your cat/dog?
Women get regular mammograms after a certain age; prostate examinations are offered if you are concerned and if anything is found then more frequent checks will be offered but nothing like annual checks for people not known to have a problem.
Both approaches have pros and cons, because while an early diagnostic of some diseases can make a huge difference, there are also false-positives and needless invasive procedures
(And I guess the people that are the most oblivious about their health are the ones that are more prone to have lifestyle related conditions - some people have never measured their blood pressure or blood glucose)
Has a proactive, annual checkup model been properly compared to doing nothing on a population level? No. But on an individual level, it makes a lot of sense.
I would say it is not useful to compare mortality rates between countries. Norway has the highest GDP per capita anywhere for example, and is quite culuturally, geographically and genetically homogeneous. How would you make a useful comparison to the USA?
Well yeah, the cost of healthcare in the US is astronomical. https://www.healthsystemtracker.org/chart-collection/health-...
This would be the same across diseases, not just cancer.
In the US, every live birth counts, even if it only lasts minutes
I don’t know if that completely makes up the difference, but the real disparity is nowhere near the numbers that get thrown around. It’s apples vs oranges.
Covid positives were a similar situation.
Most countries would not report a positive Covid patient unless the test was positive and the patient was symptomatic.
The CDC[2020] reports an infant mortality rate of <0.6%. Excluding all of it would only increase life expectancy from 78.8 to 79.2
[2020]https://www.cdc.gov/nchs/products/databriefs/db395.htm
I believe cancer is orders of magnitude easier to treat when it is still asymptomatic but detectable using metrics such as circulating tumor DNA (ctDNA). However, it is taking ages to deploy this technology because healthcare struggles with any data-oriented solution.
Innovation does not get injected top down by the omniscient insurance system but bottom up from research clinics and forward thinking doctors.
People engaging the insurance directly with an efficiency play almost always fail here. There are even some vaccines against transmissible diseases that you have to pay for as an adult. I always wonder how that can make any sense. Either the value of delivering the vaccine is less than the 10 euros they are charging me (which probably means it is not very important for me to get it) or the insurance makes a colossal mistake. Especially since most vaccines are only individually unimportant since everyone else has them.
The problem is that most healthcare systems are too fragmented and not geared towards prevention. Hence, one faces a huge uphill battle.
I guess it'd be really cheap if it was deployed nationwide. Furthermore, predictions would be a lot more sensitive / specific as they would be tuned with millions of datapoints.
It's the same for other technologies such as TCR-seq. They could theoretically bring immense prevention benefits, but it's really hard to bootstrap them without collaboration from big healthcare systems as you need thousands of datapoints to get it going. Very frustrating.
Bonus points if you can genotype them, i.e. measure common genetic variants using a chip similar to e.g. the one used by 23andme. Most tumors have an association with variants in the HLA region, and pre-screening susceptible individuals will reduce sample sizes and therefore initial costs to bootstrap.
The same applies to TCR-seq and other biomarkers which are incredibly useful to detect autoimmune disorders really early in the process.
In case you are interested in discussing this further, just get in touch via email (on my profile).
So yeah, the exorbitant costs of US healthcare do not correlate with better health outcomes. Just worse financial outcomes.
What's left when you're definitely going to buy the Cadillac is that the price depends on how much money you have, and Americans tend to be wealthy.
It also depends on factors relating to restriction of competition. If there's only so many doctors, which is the case because they restrict how many can be trained, doctors can extract more. Add to that the fear of litigation (friend dated a girl whose father made a living suing US doctors) and they end up spending money on tests that they wouldn't in the rest of the west. Possibly collective purchasing in national systems means something too, not sure.
I also think it is impossible to really compare cancer mortality between countries. My take on these figures is that given how big and dirty the USA is, they are doing remarkably well to have mortality that is significantly lower compared to smaller wealthy countries.
[1] Fig 1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641070/
[0] https://www.healthsystemtracker.org/chart-collection/health-...
Association Between Spending and Outcomes for Patients With Cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994252/
^ looks into more granular data, surveys sources that show +/0/- correlation between spending + outcomes, compares end-of-life vs non-end-of-life, cites a few studies about specific cancer types, wasteful spending. Does a better job of investigating international change in spending vs outcomes over time.
the OP globocan paper is using a country average; averages don't tell you that much, esp in the US.
cancer data is very granular these days (NY mandates per-case reporting, for example https://www.health.ny.gov/statistics/cancer/registry/about.h...). would be interesting to have a live model somewhere of outcomes by cancer, stage, comorbidity + hospital
Never saw a single bill, and in fact was paid actual money for the inconvenience of having to drive 3.5 hours to a bigger facility that had equipment the local small-town hospital did not. Also got a free apartment to stay in for those out of town appointments, meal allowance, etc.
Mum had never paid a cent in insurance premiums in her life, etc.
Do you know that your insurance paid that, or is it what you have been quoted?
US hospitals are notorious for overcharging by factors of ~10x when looking at their charge master, but the insurance companies will get a much better price after negotiating with the hospital, which is one of the reasons why the hospitals will blow-up charges in the first place, to get paid despite the insurance companies not paying everything.
It's a broken system because you need an insurance agent as a "lawyer" to get the real rates.
Instead what is necessary is price competition and transparency. You should be able to look up online the cost of chemotherapy for a certain type of cancer in the whole US, then you can filter by distance, reviews and price. The price on the sticker has to include everything. Whether you have insurance or not should not factor into the price at all.
The free market is maybe not a solution to the social problem here, but it could at least drive down costs.
They don't bear the cost so expecting the US to do better at same or lower cost is structually impossible.
I would suggest The Great American Drug Deal, by Peter Kolchinsky.
Also - https://www.rand.org/pubs/research_briefs/RB9412.html
>For example Cuban healthcare/treatment/outcome is excellent based on its own research
Cuba does not contribute substantially to global pharmaceutical research.
>Roche(Swiss) nor Merck ( German, not related to US Merck) don't benefit much (if at all) from US subsidies.
Roche makes 55% of its revenue from US drug sales (https://assets.cwp.roche.com/f/126832/x/db9d31e8a7/fb20e.pdf p22)
EMD Serono (formerly Merck KgAA) is similar.
These revenues are the topline driver of the drug development industry.
Is the cost of funding the "research complex" included in the expenditure on health care?
At least some of this cost is born by the Federal government, foundations etc, is this counted as general health care expenditure (I doubt it)
Some of the research is funded by companies - since they sell globally this funding cannot be counted as purely of US origin.
Other countries also have significant health research - e.g. UK, France, Germany - your point would also apply to them.
Overall your point is dubious, and vague - you'd need to present some solid numbers to back it up.
Specific claims:
- The US pays more for new drugs than the rest of the world
- The US contribution is disproportionate, and is major driver of the drug development industry.
-If the US paid less for new drugs, the entire industry would slow, and we would have fewer more effective treatments.
...
Routine medical procedures being crazy expensive is unrelated and pathological.
Given how pharma companies operate, I kinda doubt it.
this 2017 article[2] claims that the US pharma $ premium is more than R&D spending for 13 of 15 top pharma cos. (Note: this isn't even talking about profit, it's talking about the excess profit from higher US prices). Maybe you can make an argument that R&D is lockstep to margins, and would shrink if margins went down?
1. https://www.hhs.gov/ohrp/sachrp-committee/recommendations/no...
2. https://www.healthaffairs.org/do/10.1377/forefront.20170307....
To compare costs: For an extremely rare cancer, total cost of treatment was 100k EUR in Germany, whereas US patients report case costs of >2m USD.
Part of these savings stem from the public healthcare system not providing adequate treatment, while strictly necessary for a reasonable chance of survival in this case. What happens in Germany then is the amazing doctors do stuff anyway (if you can convince them), bill whatever they can, and write off the remainder. Profits from privately insured patients make up for this shortfall here.
Public healthcare being adequate is somewhat of a myth, for Germany at least.
It's a cynical viewpoint, but I can forgive those who think that modern health care is mostly a way to extract as much wealth as possible from sick people before they die.
When you lose you job and insurance due to health, you can not qualify for state aid if you have any assets at all. you you must spend until you are broke before you get any help. Then there is the issue of nursing homes. If you end up in one, they have the ability to unwind any asset transfers in the previous 5 years, so if you thought you can transfer your house to your children before you die, you can not. The nursing home and the hospitals will suck every penny out of an estate and the only way to prevent it is to die quickly.
And I do not need data to tell me this, just overal experience comparing it to my previous experience getting healthcare in Europe leaves a lot to be desired.
Getting medical care in US is hard with a lot of bureaucratic/insurance overhead and when you finally get to the doctor they are more prone to follow strict procedures/checklists to reduce liability instead of being genuinly curious about your condition.
And all this while most have to pay astronomical price for healthcare out of their pocket. Not sure that the case for privatised healthcare can hold up with these results.
For example, India has an official COVID death count of around 500k. The WHO has made their own estimates and believe their death count to be closer to 5 million, ten times the official number.
Talk about damned by faint praise …
See, for instance:
https://www.euronews.com/next/2021/08/05/the-real-covid-deat...
https://www.news-medical.net/news/20220427/Excess-all-cause-...
We are talking approximately 1% of the population dying each year and excess death rate being in the region of -+20% of this 1 percent. All above figures are approximate ball park figures from memory - so don't hold me accountable to the exact numbers.
India's death rate during the pandemic is between 3.5 and 4.7 million more than expected.
The US has had around 1.2 million more deaths than expected.
So something caused a huge increase in deaths. And it was obviously COVID.
Edit - your numbers are seem correct but the question is, do consider them statistically significant? For me a jump from 2.6 million to 3.2 million is still tiny.
Source: https://deadorkicking.com/death-statistics/us/per-year/
This has nothing to do with healthcare quality.
This "tragedy of the commons" with regards to medical science causes everyone to misattribute things. Europe for example can pay little money for their medical practices because of the US bankrolling the research and drug development that allows them to do so.
One route to fixing things in the US, if we really wish to do so, is to create by law a "most favored" status for the US such that if a US drug company sells outside the country, they must sell the drug in the US for the same price as the lowest price they sell it to any other country. This would largely fix our expensive healthcare, but would also harm the world heavily in advancement.
As to your first question, I don't have an answer for you off hand.
edit: Hmm, if that's true then US must be actually behind because every now and then the UK or some Europeans might invent something but the Americans won't have it because they respect intellectual property. Which means Americans will have only American stuff but the Brits and the EU will have Europeans stuff too.
- The US pays more for new drugs than the rest of the world
- The US contribution is disproportionate, and is major driver of the drug development industry.
-If the US paid less for new drugs, the entire industry would slow, and we would have fewer more effective treatments.
Do you have any articles, papers etc from reputable sources to back this up? Or is this just personal speculation?
I would suggest: https://www.rand.org/pubs/research_briefs/RB9412.html or The Great American Drug Deal, by Peter Kolchinsky.
The US is ~35% of the global pharmaceutical industry, which is the topline driver of new drug development.
When the US pays top dollar for new drugs, it does effectively subsidize European access to the new research.
>Do you have any data to backup your claim?
I would suggest https://www.rand.org/pubs/research_briefs/RB9412.html
or the Great American Drug Deal, by Peter Kolchinsky.
Drug prices are far from the leading cause of the high cost of US healthcare.
The whole system is deeply dysfunctional with massive perverse incentives.
Then you'd end up bankrupting most healthcare and pharmaceutical companies, that is if most of them don't leave the country. If the current scenario is a "tragedy of the commons" a la Guns or Butter, then the US's domestic medical policy is the biggest contributor. A "most favored nation" policy as such just allows the government to pick winners and losers by creating a de facto price control. It's not a solution and would do more harm than good.
The ultimate reason why it's expensive to sell a drug in the United States is because the FDA makes it illegal to import competing drugs. The solution is to let the market determine the "real" prices.