For things like math, science, and engineering--where the possible depth of knowledge and understanding far exceeds what could be learned in a semester course--I personally think exam grades should center around 50. If you've got 100 points to play with, why not use them?
A lot of my classes did, and I always found the challenge exciting: what stuff did I not learn about this subject? This also gives you the ability to differentiate student performance, should that be of importance.
At the end of the semester, things were usually (non-linearly) curved up to average around B. The instructors (well, most of them) knew what "absolute score" represented enough understanding to move on, and anything below that would not get curved into a passing grade.