Hydrogen leakage and structural embrittlement are overblown, i.e. the Space Shuttle tank is one of the most mass efficient architectures in history and it was full of liquid hydrogen. Terrestrially, you can buy a Toyota hydrogen car today. Materials matter, but people act like the thing needs to be made of 4" plate and will fall apart if you look at it. Scaling helps here too, as volume increases to the third power while wall area increases to the second.
The thing will, if there is any sense in the architecture, be assembled in orbit so gossamer heat shields and the like won't be a problem, nor will an extended assembly program that makes with a separately launched nuclear reactor.
For ISRU Mars return, water is incredibly abundant and there's no concern with "wasting" residual oxygen. For lunar applications, water may be scarce but oxygen is abundant in regolith.
You can't beat hydrogen as a fuel. As the lightest molecule, you get the highest exhaust velocity for the least energy input.