1) Is it resilient to catastrophic failure? Does there exist an N < 100 such that if there is an EMP, a computer virus, or some other anomaly that wipes the data from more than N% of the nodes, the block chain enters an irrecoverable failure state?
2) How scalable is it? Sure, it might work for a very small % of the world's transactions, but could it ever handle the sort of load that is taken on by say, Visa credit cards worldwide, while still allowing transactions to complete in a "reasonable" amount of time (that the average person would tolerate)? If not, what is the upper limit of requests per second while maintaining some sufficient upper bound for transaction time?
Feel free to be completely hand wavy. This is just a thought exercise for now.