Perhaps you could elaborate on what you mean, but from my viewpoint there isn't much daylight between DB-queries in most server-rendered apps vs. SPAs.

Instead of this:

    def endpointAB:
        a = db.getA()
        b = db.getB()
        return template('ab.html', {a=a, b=b})

You tend to have this:

    def endpointAB:
        a = db.getA()
        b = db.getB()
        return json({a=a, b=b})

When I think of ways you may want to generalize over arbitrary queries on the server, I run into the same challenges you'd have in a SPA rather than fewer.