If all the teams use client-side rendering, I can ship the design system as an NPM package of React components, and you can use tools like Storybook to run visual regression tests without standing up your full environment.
I know I'm speaking tactically here, but a shift away from SPAs seems like a loss for shared UI components and design consistency. I can't just give a CSS file (which is portable across tech stacks) and leave it to engineers to write accessible HTML; there's huge value-add in isolating a11y in something like a React component abstraction.