I got denied a mortgage despite have assets in excess of the value of the house I wanted due to insufficient income (wasn't working at the time).
Credit score impacts interest rate but debt to income ratio that is above 50% can completely disqualify you from a mortgage. Thats where the founder ownership can skew your personal DTI.
You can go to asset based lenders who evaluate and secure the loan against your existing assets (cash, etc) rather than based on your W2 income and DTI.