AFAIK, it depends on your bottlenecks.

In terms of actual compute speed, Python is still significantly slower, and although 3.11's changes will help quite a bit, V8 is also just insane.

In terms of I/O speed, uvloop (https://magic.io/blog/uvloop-blazing-fast-python-networking/) can beat Node quite handily, so if you're more concerned with being able to handle requests than doing anything major during those requests, Python might be comparable.