Big question: do you think business ultimately needs to make stuff? If you do, then the challenges include securing reliable raw materials now that just rocking up somewhere with a big boat full of men with guns doesn't work. Not to mention reliable energy - most customers do not like it if your delivery date depends on the weather. In fact, they really don't like it and will happily pay for some other less carbon-conscious nation to produce it on time. Oh, and having good trade relations with the exceedingly industrially capable neighbours, who should be a manufacturing ally.
But solving those requires having enough people who care. Was it Tim Cook who said something along the lines of "you could fill a conference centre in China with people who just knew about fasteners"?
If you think business doesn't need to make stuff, or "pay enough taxes and abide by enough regulations", well... I'd have to agree with neilwilson. Why should I care, because frankly, what I've seen from the last decade has been Ponzis, gambling for children, money laundering for the worst people in the world, labour law dodges, and 140 character parodies of "debate", and I'm not impressed.