Just as it did with Alpha's.
Just as it did with Itanium.
Just as it did with PowerPC.
Just as it did with MIPS.
Just as it did with Transmeta.
Just as it did with ARM last time ( https://en.wikipedia.org/wiki/Acorn_Archimedes )
The year of replacing the x86 architecture never arrives ...
Frankly, I would probably give Itanium the best odds (Intel + Microsoft behind it), then Alpha (Microsoft behind it).