We act like we know, because it's comforting to do so. Naturally we fall into patterns where we can exert control, feel we have a sense of autonomy, and have things occur with predictability.
As an avid supporter of science, I think you're quick to rely upon it. If it holds all the answers, they won't be unfolding in our meagre lifespans. What I consider greater than science, is experience. Whatever you actually experience cannot be explained away, it is the ground truth. Whether you're experiencing illusion, delusion, or confusion - they are themselves experiences and it cannot be denied that you're having them.
You find everything hollow and lacking because you're looking for meaning and purpose over there, not here. The great thing about the 'here' is it's about as solid as anything can be, and you need not seek anything more than it. It's not going anywhere, and you're welcome at any time to turn your mind upon itself. It is here that contentment, acceptance, timelessness and beauty exist. And when one is content, questions such as yours tend not to arise.
Your experience is the landscape which everything arises. Absolutely everything. Sure, there seems to be a thriving physical world beyond the bounds, and independent of, you. Though without the 'you' to experience it, it's meaningless.
You're never going to get the answers you seek. So stop seeking.
Enjoy each moment. Easier said than done right? Minds are akin to rafts on the open sea, being thrust this way and that. Sitting upon, and identifying with a torrent of thoughts. We identify with these thoughts and they carry us to and fro.
When is that last time you noticed a thought arise? For surely they do. And when is the last time you observed a thought arise, and chose not to identify with it? Thoughts are not you, for you can stand aside and watch them appear and dissipate.
Make a point of sitting back and getting comfy in the cinema of your experience. What will your next thought be? Wait and see. There will surely be one.
Did it carry you away? Do it again. You will start to see thoughts arise all of their own, and you can simply watch them. The tendency is to BE the thought, and this need not be.
The space that is left to experience in the absence of thought will ease the doubts and fear that assail your mind. For these too are the realm of thought identification.