House (or medium/large condo): bought in last 3 years $1.5mm usd
Mortgage (20% down): $105,000/year
Property taxes: $17,000/year
Maintenance: between $3600-11,000/year (including capital things like AC, roof, flooring, repainting interior, foundation amortized)
Total: $133,000/year
Family:
Grocery: $20,000/yr
Daycare 2 kids: $48,000/yr (yes daycare is $2000/mo in SF... to START)
Transportation: $8,000/yr (car payment + insurance + gas)
Annual one week "really nice" vacation: $10,000 (4 round trip tickets, 2 hotel rooms, food, transport, entertainment etc)
Misc costs: $10,000
Total: $96,000
Comes out to about $230k/year in raw expenses. These are pretty accurate for 2021 San Francisco 40 minutes walking distance from FiDi. Of course there's no way you'd qualify for an $8500/mo mortgage on that salary (19k/mo) so instead you'd have to settle for a 2 bedroom condo ($960,000? maybe? can you squeeze 2 adults and 2 kids into 1050 sq feet? long term?) for the four of you, sharing one car.
You might be able to pull this off on $300,000 with substantial help from family if they are local, but after taxes etc you will be struggling to save 1% of your income and not really building/maintaining an emergency fund or building savings for other projects/hobbies.