I've been going to PyCon since 2005. It was good to be back even if the conference was smaller than normal. Python is in a great place. It still has some warts and issues (mainly from the time it was originally developed) but it has a huge community, wonderful libraries, a steady stream of students learning it in college, a large demand from corporations for anyone who knows the language, and it is used in many domains.
The announcement of PyScript has the potential to be a game changer for many as it removes one big sticking point. Getting started and environment setup can be a pain. Hitting a URL and jumping into coding from the get go is especially big for corporate trainers like me who tend the spend the first hour or so of a class making sure everyone's environment is set up correctly.