https://cimsprodprep.cdfifund.gov/CIMS4/apps/pn-nmtc/index.a...
The purpose of the QOZ is to encourage investment in those areas, and it does this by favorable tax conditions.
Some of these areas are surprising, at least around me I see areas designated that aren't much different from the surrounding areas. And there are rural ones, too.
Looking at some of the ones above in street view, I can see why they're classified as they are, and I could certainly see a start-up choosing to place an office in one of those locations. Some are transit-close, even.