Frankly the much bigger problem is global time zones and limited overlap restricting the time available for synchronous discussions.
That plus a lot of other mind games. In a way it's a power game, whose time is more valued, who gets to demand attention right now etc., who has more flexibility and convenience...
Also, sometimes when people are confused, they sort of emotionally panic and just need someone beside them, to hold their hand and comfort them virtually. Then if you don't respond, they somehow do manage to solve their problem on their own anyway. But it felt simpler to just interrupt your work and ask you instead of thinking or searching in the internal docs etc.
[0] If I'm in a bad mood I reflect the exact sentence back, meeting "hi" with "hi" and "Hey how are you?" with "Hey how are you?", but still, it's a reply..
Though there's also https://nohello.club