What about "Depression" is a sign that something deep down is shifting or needs changing. After introspection, my loss of motivation is a lot of the times me knowing that I want to work on problems that I dare worthwhile for the future of humanity and earth like climate change, environmental work, planting trees and social work..., and being obliged to not work in that triggers the lack of motivation unless obliged by survival. I am very skeptical of medication to solve these kind of issues.

'Until you make the unconscious conscious, it will direct your life and you will call it fate.'