My yubikey is getting to about 10 years old, and I have replacements for it but find it very difficult to switch. It will eventually fail as an things do and it will be problematic.
The problem is that I have several dozen accounts connected to it and I don't know all of them. So either I'm carrying and trying multiple keys at all times or not getting into a site that haven't been rotated yet.
Multiple keys on an all sites is also basically impossible. You need to register all the keys, and ideally those keys are in different places.