How close is Python SQLite and Datasette Lite to accessing a hosted SQL database using HTTP range requests as can be done in sql.js like https://github.com/phiresky/sql.js-httpvfs?
I put together a Pyodide-based web app where users need a few indexed queries from a 600mb SQLite database but it isn't very practical for them to download the whole thing into the browser. I would datasettify it and access it by API, if I wasn't relying on a pyodide library that needs direct SQLite access.