Comment by SemanticStrengh | Hacker News Reader

Comment by SemanticStrengh | Hacker News Reader

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SemanticStrengh

It is a fundamental mistake to think those things will come in the future. They are already there, simply not prescribed for those uses. They will never be prescribed for those uses, the FDA has simply far too much inertia to allow progress in prediction practices. The good news is everything I have mentionned is accessible OTC today. Also do not mix random dopaminergic things with your methylphenidate unless your study the interactions and monitor your heart and has acess to beta blockers/benzos. If you don't tolerate vyvanse I would advise you serdexmethylphenidate. 4-fmph would probably work well for you but it is more abusable than methylphenidate and possibly more cardiotoxic. For me I couldn't sleep on it and had minor tachychardia but I am generally intolerant to stimulants (I probably have a non-diagnosed cardiac issue). Selegiline low dose or moclobemide potentiate the duration and effect of your stimulant so you should try that but as I said very careful with the effect on your cardiac rythm. titrate doses very very slowly and study the half lifes.

What are your other issues with methylphen?

Thanks for the pointers, I'll be bringing this up with some friends who work in related domains and see how to best bring this to practice.

> What are your other issues with methylphen?

Those 80mg is what I require, on average, to get the desired effects and have them last throughout the entire day.

First problem is an inherited cardio-related risk factor. Even if not an immediate concern, it is a permanent one.

Second one is that sometimes. lasting a day or two tops, methylphenidate has no effect on me - even not that high dosage. Happens with any brand/vehicle/release I've tried. Apparently this is really weird. We went to great lengths to try and figure out the cause, but there was no correlating pattern that we could find, and the drugs and production lines tested clean and unchanged. It's a mystery.

4f-mph means 4 fluorine-methylphenidate. So it is a variant of methylphenidate that is similar in effect, except it is both more potent (careful dose measurement needs a gemini milligram scale) and has a much much longer half life (once early in the morning) the fluorine is toxic in theory except its supposedly not toxic because the bond that bind fluorine to methylphenidate is one of the strongest bond in chemistry. That's why ~40% of new FDA allowed drugs use fluorine. But it can slighly alterate the binding ratio of dopa vs noradrenaline vs sert. You can buy it e.g. here https://rarechems.com + /4f-mph-hcl it has been tested by third party labs cf https://rc-scene.com/ the legal status depend of the country but yeah there is a cardiotoxic risk. I would combine with Cialis 2-5mg daily since it is a potent cardioprotector and cancel vasocontriction also I advise you to take your stim 5 day per week max, otherwise you risk building tolerance. 5 days per week might be too frequent for 4f mph, I don't know. And it's too potent to be mixed with selegiline or moclobemide.

You are just as much a hacker as any of us code-monkeys on here :)

You sharing this knowledge so freely is much appreciated. I am serious about researching and further considering every bit of it.

what are your thoughts on wellbutrin and isopropyphenidate? (not combined haha)

for ADHD welbutrin is effective but not very effective, much less than methyphenidate despite having the same action mechanism. One of the reason being that it is a nicotinic receptor antagonist, an awful property, that should be palliated by taking GTS and choline. Also it has less neural occupancy IIRC. Also wellbutrin cause a high? incidence of tinnitus

isopropylphenidate has not been tested, it is reputed to be clean and low potency. It might make sense for stimulant intolerant people since it has low side effects. Otherwise I'd go for low dose 4f-mph or 2-fma, at least if you can't access vyvanse.

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