This is a key point.
As you do when you run startups, you wear many hats, and one of the hats I frequently wore was that of interviewer.
In that role you very quickly develop a smell-test for the corporate-type.
It is an inevitable fact that the majority of responses from any job ad will come from people whose immediately previous job(s) were in the corporate environment.
That's fine, nothing wrong with that. But you have to structure your interview technique as such that you try to determine if they are more the corporate-type who has become accustomed to the cushy life of the corporate world (teams, departments, tight job descriptions, guaranteed 9–5 life etc.).
The problem with those who have become accustomed to the corporate world is that they'll never change. The mentality becomes too engrained, they seriously struggle and cause headaches for their colleagues. The more years they've spent in corprate-land, the worse it is.
I would often find the classic "do you have any more questions for me?" at the end of the interview to be the most revealing of all as to the mindset of the candidate.