MOBI is so outdated and lack many newer features on Kindle. So much so that Amazon is discontinuing sending mobi via email later this year.
If you want to publish a new book on Amazon, you have to use EPUB instead of MOBI. That's the only change afaik.
https://www.amazon.com/gp/help/customer/display.html?nodeId=...
Maybe a few thing more, but these two are what put me off of using MOBI. (I believe there's a hack for jailbroken kindle to fix this)