This uses Pyodide [0] under the hood [1], which is CPython compiled to WebAssembly. In all my tests of it, loading takes a long time ~5 seconds. Coldbrew [2], another distribution of CPython on Wasm, is another option with similar load times.
And Brython [3] is a completely different option without long load time: a Python interpreter implemented in JavaScript.
If load time is important, Brython is pretty nice. If feature completeness is important, Pyodide and Coldbrew are probably best.
[0] https://github.com/pyscript/pyscript/blob/main/pyscriptjs/sr...
[1] https://github.com/pyodide/pyodide