While you make your opinion harshly, I have to agree completely. Marco is an intelligent, driven guy who has been successful with Instapaper. It's a shame to hear him complain so much, and I've stopped listening to Build & Analyze as a result.
You know what I'm talking about. The new guy that's quiet because no one knows him outside of "hey, he's the new guy." But as you get to know him, and he becomes more comfortable he starts to show who he really is as he becomes more outspoken.
Now, I don't want to say to not be yourself, and you can't please everyone. But I preferred the first 5-6 episodes of B&A over all the others. He was humble and interesting. Somewhere between 7-15 the humble was disappearing and the interesting vanished.