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I wrote an article about OpenSSL some time ago, and it's Google's top hit on "openssl flat file encryption."

I've heard great criticism of directly using the RSA functions, but they do work for the exchange of a very small amount of data.

Newer versions of OpenSSL offer chacha20-poly1305 in the "enc" symmetric ciphers.

I use p7zip for encrypted backups, even though the AES implementation is far from best practice.