* submarines deploy for 3-6 months at a time, often-times rarely pulling into ports. Imagine being stuck with 130-150 of your closest friends for that period of time in close quarters. It gets weird.
* Law of Conservation of Happiness: Once you're submerged, happiness can be neither created nor destroyed, it can only be taken from others. Easy for the CO/XO to be happy: they run drills & have cleaning days for the crew. But everyone learns other crew members' weaknesses and ruthlessly exploits them if necessary.
* Fatigue. I understand it's changed but when I was a submariner the boat operated on an 18-hour cycle: 3 sections of 6-hour watches. Humans aren't meant to operate on an 18-hour day, and so within a day or two of getting underway you just get into this permanent semi-fatigued state.
As for me, looking back on my time I enjoyed it and learned a lot. (Maybe more importantly, I learned a lot about myself.) That said, while I was on board it was a lot more difficult experience - it's a challenging life.