Here's my setup on a standard Apple Magic Keyboard:
caps lock -> ctrl
tilde -> escape
left ctrl -> tilde
I borrowed this from the Happy Hacking Keyboard layout and haven't looked back since. I can now press escape with my left ring finger (right next to '1'), ctrl with my left pinky (right next to 'a'), and when I do need to type a tilde or backtick (not often) it's right under shift. On some keyboards I also map backslash to backspace and vice versa, to bring backspace closer. No more finger stretching!