For low-latency strategies, AMD's lack of DDIO [0] makes it a non-starter. The memory latency is a big gap to close.
[0] https://www.intel.com/content/www/us/en/io/data-direct-i-o-t...
[0] https://www.intel.com/content/www/us/en/io/data-direct-i-o-t...
There was a great presentation from 2017 about some of Optiver's low latency techniques[1]. I had assumed they released it because the had obviated all of them by switching to FPGAs, but I don't know. Either way, he suggested that if you ever needed to ping main memory for anything, you already lost. So, I wouldn't have thought DDIO plays into their thinking much.