One of my favourite quotes (no idea who made it) is that in all of human history, the death rate is exactly 100%. Outside of people's religious beliefs (Jesus, Lazarus, etc) and fiction (vampires, sci-fi, etc), we'd all agree that no-one has escaped death.

The death rate is 100%, no-one gets out alive. So we should get as much out of this life as we can. What that means for you can differ from others, but to me that's a central question as we enter middle-age.