An open question would be wether the baseline inflammation level could be lowered if we implemented a periodic but rarer higher inflammatory level.
So a ~flatline vs a sinusoid. It could be pharmacologically simulated.
However it also releases endocannabinoids, which are anti-inflammatory, and causes a host of metabolic changes which are also anti-inflammatory.
The overall effect of exercise is to increase inflammation acutely, and to decrease it chronically. Regular physical exercise is overall more modulatory than inflammatory.