I really don't know how to square that with basically everyone else in the space being clearly morons or hucksters.
The problem (like many others) is that Vitalik doesn't necessarily think practically about the situation. For example, how do you explain to my grandma that the fork of BTC is the newly reached consensus or the original one? Vitalik would have an answer for this, but it's not a practical one.
Lucrative opportunities attract frauds. The dot com boom attracted frauds, was the internet a big scam? Literally every technological development in history that was potentially very lucrative attracted swathes of con men. For every stock worth purchasing there are a dozen garbage ones. For every innovative product you can buy online there are dozens of cheap worthless pieces of junk. The fact that idiots and scumbags are attracted to crypto only means there's money to be made, it says nothing about the actual utility of the technology.
https://en.wikipedia.org/wiki/Argument_from_authority
https://en.wikipedia.org/wiki/Argumentum_ad_populum
Granted, the crypto debate on HN is pretty well hashed & Guido's tweet doesn't add anything to the discussion besides making clear where he stands on the issue
This is a classic example of the Halo Effect (https://en.wikipedia.org/wiki/Halo_effect).
I trust his intellect and judgment for Python, and that's it. I don't trust him for programming in general, for example, let alone a completely different arena.