I tripped and it reset my brain in fundamental ways. Felt like an operating system reinstall.
I suspect depression medications may inhibit the effect?
There's some charts floating around about it on the internet: https://wiki.tripsit.me/wiki/Drug_combinations
Educate yourself thoroughly on what effect such combinations could have before you even think of doing this.
Combining drugs in general is often a very bad idea, and many overdoses and other adverse reactions have been due to this.
1. Someone taking SSRI's and psilocybin finds that the dosage... simply doesnt work. I had one individual who ate up to 8! grams before seeing and feeling things that I would see in normal people at about 1.5.
2. This might be really bad for you! There's some evidence that mixing that level of both drugs might be not good for your liver and might get you into toxic levels, and suggests tapering - I honestly dont suggest tapering your anti-depressants unless you are working with a medical professional because well, suicide.
3. If you really want an undenyable trip, just take some salvia (properly), 15 minutes and many of the same after effects.
When I was on Wellbutrin, it stopped the mental effect of alcohol. When I imbibed, there was no loss of inhibition normally associated with alcohol use. However, I did still lose physical coordination.
Zoloft did not have the same effect.
The brain is a crazy thing.
In general I think this is most pronounced even within antidepressants of the same class, with similar binding affinities, some people report limited success with one or the other seemingly similar drug.
All this said, wellbutrin is a very different drug than zoloft. It have more dopamine and norepinephrine activity iirc.
Also for anyone else, try to avoid alchohol and wellbutrin or take it knowing that your seizure threshold goes down on wellbutrin so its easy to black out and do worse than you realize (also related to the reported effects above)