Not doing anything new in recent years but Qt is definitely a joy to work with.
From MVC on data management in the widgets, networking, UI handling and tons of customization.
The Qt Creator IDE was the fastest IDE I've worked with and very helpful with Qt Designer integrated.
Dealing with system icons in Linux or i18n, tooling, compilation and building and so many other really complex stuff is pretty damn easy with Qt.
Although I've used Qt/C++ and never the Python binding.
Thanks for all the hard work and amazing people behind it.