If you can setup HPC at scale you can setup Ceph for object storage. It will save you so much money in the long run.
Ceph/Object storage comes into its own at the multi-petabyte and higher levels, which is not very many groups or institutions.
Ultimately you just have to design for what is important to you; I don't want to spend time managing this stuff any more, so keep a local NAS for my partner to access and put the bulk of my "cold" data into 2 different cloud object storage providers. Note that neither of these is actually S3; for business use I would absolutely use AWS but for personal files I can manage with the reduced capabilities and lower prices others offer.