On the outbound side, many accepters of mail will deny mail from SMTP servers on a residential IP address, as provided by the Spamhaus Policy Block List (https://www.spamhaus.org/pbl/) or equivalent. Unfortunately, there's not much one can do to get off this list - ISPs self-publish their own residential IP space onto it. In order to self-host from home, business-class service or higher is in order. Or, again, use the public cloud, and hope your compute instance's IP isn't on some other block list.
On the inbound side, though, many ISPs block inbound port 25. Since that's the agreed-upon port for mail receipt, there's no real way around this. Several times while I self-hosted off residential, I was able to call Comcast support and ask for the ban to be lifted, but not before fighting through several layers of level one support asking me to configure my mail client differently. The real kicker, though, is any time my modem was rebooted (I owned my modem, too!), I had to call in and request it _again_. My (very small local) ISP in upstate New York also performed this blocking, but _would not_, in the face of any complaining, lift the block.