IMO all of the comments about Wolfram as a topic are low quality, including this one.

The topic of the post is the "Wolfram Institute". I'm happy to see more investment in R&D, period. Good on Wolfram.

I will probably never seek out a job at the Wolfram Institute because I believe the title is true -- there is an abundance of scientific opportunity. Working on Wolfram's agenda would not be the best use of my time, in part because the Wolfram Institute likely won't have the resources or interest to exploit the scientific opportunities about which I'm most excited.

This is less a reflection on Wolfram than on the state of the world. Theoretical Physics of the sort Wolfram was imbued in his early career had its moment half a century ago, but has not produced fruit in a long time. I doubt that will change -- in part because even if all the stated problems were solved... so what? Similarly, computation systems seem to have hit a fevered pitch in the 2010s and are now approaching a plateau.

There are exciting opportunities in the life sciences, in robotics, and in AI. But the Wolfram Institute would be a bad place to work on those things, and in particular likely does not have the funding or expertise to do ground-breaking work in the life sciences.

I'm sure there are many who disagree with me, and I hope they find the Wolfram Institute to be a happy and productive place to do meaningful work.