Based on a quick check of their Wikipedia page, Nix has been around for 15 years, since 2007.
So those for sure look like structural problems. I don't know which ones exactly, but paraphrasing Tolstoi, popular software products are popular in much the same way, while unpopular ones are unpopular in their own unique ways.
In my experience almost no open source project that hasn't entered the mainstream in its first 10 years manages to turn the ship around, unless it lucks into a major change of environment. Programming languages are sometimes exempt if they have a "killer" library or framework pop up.