I guess the inclusion of Murray (the talking skull) makes The Curse of Monkey Island canon then? :)
> All the games after Monkey Island 2 don't exist in my Monkey Island universe. ...That doesn't mean I won't steal some good ideas or characters from other games. I'm not above that.
So it can be both! Monkey Island 3 is no longer canon (which is a shame because it's fantastic), but also Murray can be upgraded into the canon universe anyway (TV Tropes would probably consider this an example of a "Canon Immigrant").
> MI3 doesn't go out of canon. We were very careful about that. Murray is in this game.
- Ron Gilbert, https://twitter.com/grumpygamer/status/1511022135191384067