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The part about B3 sounds very interesting but whats a prostaglandin flush?

Your skin turns read and feels hot, like a sunburn. It's the number one side effect of high dose niacin. There are some prescription extended release prescription niacins to reduce that effect, but it still happens. It's very uncomfortable, which is a real problem for something you take daily.

niacinamide (the amide form is post chemical reaction). https://en.wikipedia.org/wiki/Niacin#Adverse_effects

https://en.wikipedia.org/wiki/Tryptophan#/media/File:Tryptop... Tryptophan -> 5HTP -> Serotonin Tryptophan -> Nicotinic acid -> Niacinamide

One thing they dont mention about nicotinic acid is it will soften your bones possibly because prostaglandins uses calcium inside the cell to rebind DNA. So then it becomes a case of take some K2-mk4 to help repair your bones, and thats when people are forced to explore the chemical pathways inside their bodies to compensate for other effects which perhaps they dont want.

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