I totally agree with O'Reilly, Companies like Slide and RockYou do not deserve half a billion valuation and I am pretty much sure Max Levchin can do better than make social apps for Social-Networks.
Television and other ad funded entertainment are certainly not small business.
I think what O'Reilly was getting at was people forming their startups that essentially chase the latest trends in what now amounts to a bubble. He makes a valid argument and we could all be looking back at what he said in the future and only realize then just how spot on he was.