I expect it to be friendlier to bikers and pedestrians than human drivers.
As a biker, most of close calls are due to impatient drivers who try to overtake me through close calls and when they enter turns without looking first. AFAIK, Self-driving cars do not initiate same-lane overtakes and can be hardcoded to be paragons of patience.
With how hostile American drivers are towards bikers, self-driving cars would need Skynet-esque malice towards us to match those injury rates.