Rare genital defects seen in sons of men taking major diabetes drug
science.org
science.org
Metformin is a drug that men are probably 100x more likely to be on at 45 vs 25. Therefore men on metformin are far more likely to be reproducing with older (and likely obese) women.
I’m not saying this explains all the correlation, I’m just saying if the study doesn’t really make a good effort at addressing these confounders, its not worth reading.
The exact adjustments made can change the solidity of the finding into anything from "rock solid" to "complete trash". Seemingly solid studies are routinely trashed by third party method reviewers that the initial peer reviewers missed. So we'll know better when they get around to it.
If they didn't adjust for obesity, then it's really pointless to attribute this to the drug. Age and smoking status is not enough.
Also not adjusting for confounders is statistically ridiculous. As well as n=13 studies.
> the researchers saw no effect in offspring of men who took the drug earlier in life or in the year before or after the 90-day window of sperm production. “It really has to do with taking it in that window when the sperm … is being developed,” says senior author Michael Eisenberg, a urologist at Stanford Medicine.
See my other comment where I link it to a functional zinc deficiency.
The authors have done a lot of tests here. If you do enough tests, even on null data, you eventually get false positive results. Nevermind the effects of confounding which are difficult to control for effectively in a non-random study.
The smallest p-value I could find was P = 0.012. Which is for "elevated birth defect fre- quencies among metformin-exposed offspring". This comes from a table with 6 rows of models with different OR values. Presumably they did have p-values testing if those ORs were statistically different from OR == 1. Which means one should adjust p-values by dividing the significance threshold by 6. So, 0.05/6 = 0.0083 which is smaller than 0.012. So I would be very hesitant to say that the evidence points to metformin really causing this. At least based on this study.
Also, adjustment of the p-value doesn't do anything to solve the flaws of hypothesis testing. But that's another debate entirely.
https://www.acpjournals.org/doi/10.7326/M21-4389
Looks like of the kids taken from dads taking metformin, .9% had a genital defect, which seems pretty high to me (defect in control is 0.24%). Granted, not as high as Thalidomide, but still, 9 in 1000 are not great odds.
From NIH.gov:
"In the United States, a rare disease is defined as a condition that affects fewer than 200,000 people in the US."
To be clear, spermatogenesis takes roughly 75-120 days, so this is consistent with metformin causing genetic changes to the sperm when or after they are formed, with those genetic changes being propagated through the germ line to children conceived by the sperm. But it's true that the (very preliminary) data does not suggest that this is causing permanent genetic changes in the father.
Good luck future humanity.
I ask this as someone with a BMI of 23 who puts a reasonable amount of effort into not becoming obese or overweight again. The personal benefits of not dying from cardiac arrest at 55 are very obvious, but I'm not clear on why healthcare systems won't be able to cope.
I can understand the argument that diabetes resources, specifically, will be strained. If overall costs don't rise, that's not a huge problem.
https://www.niddk.nih.gov/health-information/health-statisti...
Doctors are now seeing children come in fatty liver disease. That never used to happen.
They used to die of malnutrition of all kinds. Not just because of being poor, but because of us not knowing this or that is necessary in food.
The physical work people used to do was body breaking fairly often. The chemicals people used to be in daily contact with were body damaging too.
It is missing Iodine which is now commonly added to salt.
You can be overfed in calories and still suffer from malnutrition. Especially without science we have now. And whole classes of sicknesses caused by malnutrition don't exist anymore.
In general, we live in a healthier world. We know more about nutrition, cancer-causing chemicals, etc. We continue to make progress automating some of the most body-breaking jobs. Most of us (western world, anyways) have access to clean water.
But, a substantial portion of the US (and world?) population is making bad decisions about their diet which have life-altering side-effects like diabetes. The question then is "why?" We know a lot about nutrition and it's impact on our bodies. Is it advertising? Is it cost (McDonalds is more sometimes more affordable on a time+money basis than home-cooked food)? Is it just our tiny lizard brains REALLY like salt and sugar and Nestle etc know how to manipulate that?
My grandpa went through this in 2020. He was a tough navy guy, and even he said "This is a half-assed way to live", stopped the dialysis, and passed away a few weeks later. Once you're on dialysis, there's not much of a chance of going back to a life without it.
But it's not absolutes. Anyway yeah, some lifestyle choices need to be addressed to reduce pressure on the health care system. Like how for two years now we've had certain measures in place like social distancing and facial masks, not to eradicate the virus (that would require extended full stay-at-home mandate lockdowns) but to keep pressure on the health care system manageable.
IInsurance for me should be very low. I am in great shape by anybody's measure. But all the drunks, junkies, fatties, make my payments so high I've debated dropping medical insurance.
Corn is a subsidized crop by the US Department of Agriculture—we pay farmers to grow it. See the documentary "King Corn" about two guys who didn't know the first thing about growing corn but still made a profit on 1 acre of corn [1].
It's often said your zip code is a huge indicator of many demographic stats and what food you have access to is one of them.
I've lived in food deserts and I can tell you getting healthy food can be quite an arduous task, especially if you rely on public transportation.
Recent data shows that 80%(!) of black women in the United States are obese [2].
This isn't an organic phenomenon; this level of obesity is the result of a system—some intentional and some not—at work.
[2]: https://minorityhealth.hhs.gov/omh/browse.aspx?lvl=4&lvlid=2...
Except for the fact that poor immigrants from Bangladesh or Africa do not suffer from the same problem in the first generation, because they are still used to buying staples in the market and cooking traditional meals at home.
The same can actually be seen in UK and Western Europe.
The deadly fact that is compounding the situation is that cooking skills haven't been passed down in a large portion of the Western population for almost two generations now. People who do not know how to cook rely on highly processed stuff that can be heated in 2 minutes in a microwave. Reliance on this highly processed stuff is strongly correlated with bad health outcomes.
People either feel that they don't have time to prepare and cook or they see it as inefficient since it is much faster and cheaper to dine-out or takeaway.
Give them a a couple years or so, and many of them will want to live the American lifestyle - eating out every day, and stocking their pantry with snacks they see on TV. The ones that don't face the consequences of being obviously foreign.
In America, marketing and psychological hackery are second only to law in terms of "forcing" people to do things.
That's what food desert means. As in, no food. Therefore food must be imported. Therefore it's expensive. Sugar just happens to be a well-preserving food.
The solution is quite simple: Don't live in a food desert.
For the people on HN who tend to skew towards wealthy white-collar work this is fine advice, but it's absolutely not possible for a lot of people from lower incomes. Not only can they not afford to move, they can't afford to leave their entire social support structures and build them anew.
I hate calling out privilege but this just smacks of privilege.
https://files.eric.ed.gov/fulltext/ED050960.pdf#page=10
"The time has come to ask what level of population growth is good for the United States. There was a period when rapid growth made better sense ks we sought to settle a continent and build a modern industrial Nation. And there was a period, in the 1930's, when a low birth rate was cause for concern. But these are new times and we have to question old assumptions and make new choices based on what population growth means for the Nation today."
None of the authors of that paper were elected officials, and that view never became policy of any state.
Not officially anyway: https://wtfhappenedin1971.com/
If you fuck up the gene pool to get to that result I don't think you can call it "desired".
Hopefully, gene editing obviates the these concerns.
Type 2 diabetes is an acquired and reversible disease that follows insulin resistance and it is caused by excessive amounts of glucose in your blood, which forces your pancreas to release an ever increasing amount of insulin which then is absorbed by fat cells until they hit insulin resistance, then it fills up muscle cells including your heart until they hit insulin resistance until the only place left for the glucose is inside your organs.
The easiest way to reverse diabetes or avoid heart surgery is to get a live glucose monitor and then do a ketogenic diet. It's non invasive and if done correctly is more effective than any surgery can ever hope to be.
As my endocrinologist put it, diabetes is a disease about decision making.
Right now, there’s little evidence that a CGM actually helps Type 2 patients make better decisions. More information doesn’t lead to better decision making. Better decision making processes and changes to lifestyle lead to better decision making.
From 2020:
“Although continuous glucose monitoring may benefit patients with type 1 diabetes mellitus, there is limited evidence that it offers similar benefits in patients with type 2 diabetes, regardless of whether they are taking insulin.”
“Until we have research supporting continuous glucose monitoring for patients with type 2 diabetes, especially those not receiving regular insulin injections, there are no patient-oriented benefits to justify its great expense and additional hassles for patients and physicians.”
What I will do is a simple web search: https://pubmed.ncbi.nlm.nih.gov/18197594/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463748/
To quote the later study: "Given that risk for diabetes and its complications is linked to both genetic and environmental factors, it is not surprising that there are now more than 1,000 articles that address the intersection of diabetes and epigenetics or epigenomics"
The case study that I remember was studies done on Indigenous populations when they got introduced to a west-style diet by being integrated into west society. The following generations had higher rate of type 2 diabetes compared to children of existing demographics. There has also been a plentora of studies done on children born after the dutch hunger winter (https://en.wikipedia.org/wiki/Transgenerational_epigenetic_i...), where one of the finding was increased risk of glucose intolerance in adulthood.
It was my doctor's first resort for me, but the side effects were too severe and I stopped it. He vaguely mentioned that it would help if I lost weight, but made no mention of what actually resolved my diabetes, a low carb diet. I hope that becomes the first resort. Apparently around here it's not even in the standard toolkit.
This is just flat wrong and borders on malpractice for deceptive counseling. Even if a patient is unlikely to accept an option, they still need to be presented with the best/standard options. This is also the lowest risk and highest gain option with a proven track record. I would stop seeing a doctor who is not presenting all the standard options and would rather just have me pop pills.
It happens and I don't agree with it, but I totally understand why they do it. General practitioners and family practice doctors see dozens to hundreds of patients every week, and they get maybe half an hour with each patient and they know that out of the 300 people they see, maybe two or three of them will actually commit to the lifestyle changes they need to control their condition. So instead they optimize for what's going to work for the majority of their patients and skip straight to medication.
If you put it as:
- exercise to live longer and healthier, to have a better life in literally every aspect
vs
- take X and Y pills until you die, it'll cost you up to xxx thousand dollars over your lifespan, will cause serious side effects and will not solve the root cause
I bet people would be at least consider the first option.
The problem is that the pharma industry works the same way as the food industry, their business model is to sell you things you need on a regular schedule and the for as long as possible.
Not trying to discredit medical professionals or the amount of work they put in. I'm sure the majority are intelligent, conscientious and good at their jobs.
Literally the top of the 'treatment' section on WebMD:
> Managing type 2 diabetes includes a mix of lifestyle changes and medication. Lifestyle changes: You may be able to reach your target blood sugar levels with diet and exercise alone.
And the section on preventing type 2:
> Adopting a healthy lifestyle can help you lower your risk of diabetes.
> Lose weight. Dropping just 7% to 10% of your weight can cut your risk of type 2 diabetes in half.
> Get active. Thirty minutes of brisk walking a day will cut your risk by almost a third.
> Eat right. Avoid highly processed carbs, sugary drinks, and trans and saturated fats. Limit red and processed meats.
When he saw that I was losing weight and that my A1C was heading downward, he asked what I was doing. I told him about the carb restriction. He looked down, smiled, shook his head, and said nothing. That was the end of it.
I'm sure half of them are below average
Unfortunately I have also encountered an about equal number of medical professionals who have been grossly incompetent.
What I consider to have been by far the greatest mistake that I have made in my life, a mistake which had irremediable consequences, was to have excessive faith in the competence of some well-paid medical professionals.
Both my parents had the bad luck of being misdiagnosed the first time when they had some medical problems (for completely unrelated causes). In both cases the correct diagnostic was discovered by other medical doctors, but only after many months, when their conditions had become much worse.
Because of the delayed diagnostics, both their lives were shortened by maybe 4 to 5 years.
After the correct diagnostics, I have read the appropriate medical textbooks and I have discovered that in both cases my parents had presented the typical ensemble of symptoms described in the textbooks, they were not some weird cases, easily misdiagnosed.
For the correct diagnostics, the first doctors should have recognized the textbook symptoms and they should have sent them to the appropriate investigations that were necessary to confirm their maladies.
Instead of that, they have chosen the lazy way of saying that they do not need any further investigations because old people complain all the time for various minor problems and they have prescribed them some useless treatments.
If I would have been more skeptical about medical fallibility, I should have sought a second opinion since the beginning, but unfortunately I did not.
why would someone need to go to a doctor to tell them that
Nothing wrong with starting on a therapy while trying to institute a diet and exercise change. The doctor would be negligent if they said "let's try diet and exercise", then after 6 months of damage say "nope, that didn't work, let's try metformin".
It's something else to not even counsel a diabetic about carbs.
Most people in the US live in poverty and make marginal spending food decisions based on money per dopamine reward unit rather than optimizing nutrition. McDonalds is cheap and unhealthy; fresh fruits and vegetables and the free time to educate oneself on proper nutrition, then cook healthy meals and do meal prep often cost more money and time than most can afford. As does proper exercise when you’re working 12 hours per day trying to make ends meet.
A less harmful way to phrase your point is that medication can help people who self-medicate with food overcome metabolic efficiency. I lost 40 pounds on semaglutide (Wegovy) so far this past year and dropping; exercise and diet alone didn’t work for me. I hope to eventually not rely on medication to maintain a healthy weight.
> Prescriptions of diet and exercise are ineffective
Which seems to be true. If any advice your doctor could give yields no measurable difference, is there really a point to giving it?
That's very much _not_ the same thing as a doctor recommending or prescribing them having any effect.
If it doesn't have "any effect" then I guess all type 1 diabetics are already dead?
The point still stands - doctors should be counseling diabetics on dietary changes, even if they are being prescribed medication. Some patients can improve their condition and overall health to the point that they can stop the medication. If you disagree with this, please, show me some sources. As for mine, you can check the AMA, AHA, ADA, and PubMed (American Medical/Heart/Diabetes Associations).
It's a multifactorial problem.
Not saying I know any better, but at it's face I don't buy this. The change in day-to-day activity doesn't feel like it would account for the difference from just the 80s to now.
> while the calorie inputs available cheaply dramatically increased.
This I buy much more, confounded with maybe the specifics of the nutrients available.
But you're not factoring in the fact that as your weight increases so does your idle energy costs, meaning that as you gain weight you burn more calories doing nothing. Put another way, if today you burn 1500 calories a day idle, and you start eating 2000 calories a day - at some point you will reach an equilibrium, likely well before you're obese.
I'm also in the camp that thinks that lifestyle explanation for rises in obesity is completely unsubstantiated.
High-fructose corn syrup has been added to so many foods that didn't have it 10-20 years ago.
The second or third ingredient on a bottle of ketchup, for example, is high-fructose corn syrup. You can get ketchup that doesn't have high-fructose corn syrup added to it; often it's a natural or organic brand that often costs more than the regular brand.
And depending on where someone lives, brands without refined sugars may not be readily available. Google "food desert" and see what comes up.
It was literally impossible a generation or two ago to ingest the amount of carbohydrates the average American gets just from eating prepared and processed foods today.
We should just count ready-meals etc. as 'fast-food' too, no good reason that it implicitly refers to 'restaurants' only really.
> The second or third ingredient on a bottle of ketchup, for example, is high-fructose corn syrup.
Interesting, that didn't sound right to me (but it has been a long time since I've had it) - found this: https://www.truthorfiction.com/heinz-ketchup-ingredients-u-s... (tldr just sugar in the UK)
Edit: or let's take a look at cheese. I've found some pretty expensive cheese in my fridge, packed into small cube boxes, because otherwise its price per pound would be offensive. So we might expect that cheese would do better than cookies. The nutrinion facts label on its reverse begins with "serving size: 2 table spoons, 120 calories" - a borderline fradulent label that's trying to hide the fact that the small chunk of cheese has 600 calories in it.
It’s also quite harmful to dramatize the solutions out to be something unattainable to many people. They are attainable to all people. The healthiest diet I’ve ever eaten was also the cheapest diet I’ve ever eaten, and almost everybody can get 30 minutes of low intensity exercise a day.
To take an example, my self, I am doing intermittent fasting and do moderate intensity exercise everyday for at least 30 minutes(gym, cycling, bouldering, etc). No matter what I do, I still have a muffin belly.
Until one day I began to both weigh myself each day at the same hour with a precise digital scale and also weigh or measure by volume all the food that I eat.
After that moment, I reduced my weight by 2/3 and I have maintained easily any target weight. Even now, after some culinary orgy I easily gain a couple of pounds in a day, but then, by eating only measured quantities of food, I lose them after a week.
The reason why I have failed to control my weight during many years and most people also fail, is that if you eat until you are satiated, then it is guaranteed that you will not be able to control your weight, no matter how much exercise you do.
If you measure what you eat and you only eat pre-planned quantities, it is trivial to reduce how much you eat until you see that the next day you weigh slightly less (e.g. 100 grams less). Then you must keep eating such quantities until you reach the target.
If you do not respect your plan and you eat random extra snacks or drink sweet beverages, then of course you have no chance to control your weight.
It is much easier to follow a plan when you eat less meals per day, because they can be larger. When eating small meals many times per day it is far more difficult to stop after eating just a little. It is much easier to not start eating.
You mean like a politician promoting obesity inducing foods?
If it is really about individuals then obesity shouldn't be going up in African nations that quickly.
This is false. Of course certain foods are metabolized in ways that are more likely to lead to obesity than others.
Most cities and towns have little walking or public transportation. Cheap, high-calorie, nutrient-poor food is easily available anywhere 24 hours a day. Restaurants have an abundance of large amounts of meat and carbohydrates drenched in low-quality oils and sugary seasonings.
You have to be consciously active to stay fit or cook the majority of your own food. People in a lot of other countries stay lean and aren't as obsessed with fitness as we are.
I don’t really have a point, but there is a lot of poison for body and mind in that country.
Time: it costs about 20 minutes to cook a simple, basic fresh meal. With a single weekly groceries delivery (or visit to the store), you're covered for some 5-6 main meals as well as breakfast and lunch. Are you telling me Americans don't have 20 minutes to prepare a meal yet do have that time, or more, to eat out? I've been home cooking 6 days a week for 2 decades. It costs LESS time, not more.
The average American watches over 3 hours of TV, or TV-like experiences in their leisure time, but they don't have 20 mins to cook a meal? I guess they all get home from work and fall asleep?
Costs: Rice, potatos, bread, vegetables and lean meats...please do the math for me how this is unaffordable? They are incredibly cheap commodities.
"Most people in the US live in poverty".
Now they do not. The US is in the top 5 of median incomes worldwide, one of the richest countries in the world. If you dismiss Luxembourg and UAE, the USA is in the top 3. It's not a monetary issue.
Further, 12 hour work days are an anomaly, not a standard. And even 12 hours is not an excuse. Exercise isn't the core of the issue, junk food is.
Time needed to educate on nutrition: your parents or school should have done that, but here goes: don't eat garbage. Cut down on fats, sugars. Education completed. But it's not an educational issue as the person sitting in McDonalds knows exactly what's up.
It most definitely is a willpower issue as every other excuse does not hold ground. People in other countries have less time and less money, and still don't have this issue at this scale.
Please know that this is a not a burn at obese people, I fully sympathize with the difficulty of lifestyle changes, even more so in a culture like the US where the environment seems stacked up against healthy eating.
But we need to attempt to come to real and realistic root causes, and time and money are not the core issues. It creates this illusion that if only economic conditions would improve, we'd all be eating healthier, which is false.
The issue is cultural.
Ubiquitous coffee, economic pressure, overpriced and weak preventative healthcare system, social pressure, status anxiety, housing insecurity, political threats, public-facing crimes, rampant racism. These all test our self-control around food.
Like I said, home cook 5-6 days per week, which costs little time or money. None of the issues you mention prevent you from doing it. Exercise costs no money at all.
I don't mean to dismiss your reasons as if they don't matter at all, I'm stating they are a trap. They provide a shield to hide behind. If only all of that would improve, I'd be healthier. This imaginary utopian society will not make you healthier. You become healthier by stop eating crap.
Nobody's going to do that for you, but you.
Research continues its trend against this statement.
1) One problem is the fact that the number of fat cells in the body is conserved after some point. So, if you grew lots of fat cells as a child, sucks to be you, you're now stuck with them as an adult.
2) Caloric consumption has been tracked and cross referenced between countries, and obesity doesn't always correlate with it. Apparently, there are other things going on. Some of these seem to be environmental.
3) Fat cells "remember" your weight when they were formed. Once you become obese, your body fights your attempts to lose weight all the way down until those cells die off and are replaced (about 10% per year or so). It takes MASSIVE amounts of willpower to fight your own body over years.
4) Exercise is practically useless for weight loss. The body demands a fixed number of calories (up until you're doing something at the level of extreme training) and shunts the available calories between systems. Exercise has lots of benefits. Weight loss just isn't one of them.
5) I do agree that nothing in the US helps you avoid gaining weight. Portion sizes are gigantic (a "personal" pizza in the US is a full pizza in Naples). Walking or bicycling is rarely useful for most people. Sugar gets added to everything (For example: Austin, TX has been a particular victim of this--gigantic glasses of unsweetened iced tea used to be the default a decade or so ago but has been replaced by sweetened or double-sweetened iced tea (which used to be limited to the Southeastern states)).
I know these theories about the number of fat cells and about their slow replacement, etc. Nevertheless, they do not match my experience.
I have been obese during about 15 years. Then I began to measure precisely the quantities of food that I eat and after almost a year I reduced my weight to only two thirds from that of the previous year. Since then, another 15 years have passed, during which I controlled easily my weight, also by eating most of the time only carefully measured quantities of food.
During my weight loss, I was concerned about possible problems, precisely because I had also heard these theories about the fat cells that you have mentioned.
However, I have not seen any evidence for them. Before losing weight, climbing stairs was difficult, it felt like carrying a huge backpack, and I could not even see my lower body due to my belly.
After losing weight, not only all physical activities became easy, but even if there was a very large reduction in waist circumference, so initially the skin remained rather loose, after not a long time it adjusted, so no signs of the former size remained.
There were no problems whatsoever caused by the weight loss, but I had to retain forever the habit of eating according to a plan, because any day when I eat outside the plan, I immediately gain weight.
If you do not eat enough food to keep alive all your cells, some cells must die (after you have already consumed most of the internal energy supplies stored in fat). It is very unlikely that your internal regulation mechanisms will not ensure that the unused fat cells will die before cells that are in active use, e.g. muscle cells. So that theory about the constancy of the fat cell number can be true only while you are still eating some excess food or while you have not lost most of the fat reserves yet.
Strength training, on the other hand, is (at least I hear) helpful in losing weight.
This is sort of true but also sort of not. The body doesn't require a fixed amount of calories exactly, a specific body composition does. If you put on muscle the amount of calories the body demands goes up.
Low carb eating has been successful outside of the mainstream lie of "eat more whole grains" because it simply avoids the foods that worsen runaway metabolic syndrome; the common advice is just to "eat less", while these poor people are ravenous and gain fat on whole foods 2,000 kcal diets. CICO doesn't mean anything in a vacuum if one way of eating causes you to be constantly hungry, and the other teaches your body to make use of its great amount of stored energy.
Obesity is eating the same food that previously kept you healthy, but now makes you sick and hungry.
Here's abundance of doctors and researchers talking about it: https://www.youtube.com/c/lowcarbdownunder/search?query=diab...
Here's one I've watched and can recommend: Prof. Robert Lustig - 'Sugar, metabolic syndrome, and cancer': https://www.youtube.com/watch?v=jpNU72dny2s
It took me four years to force my doctor to test my serum zinc levels. When she did they found I was deficient. She did not know what to do, nor did it even seem to impact or shock her.
Zinc sulphate gave my life back to me. (Lupus, mood disorder) You would think that my doctor would share this with everyone. But no.
I think my issue was I was already disabled and on Medicare diagnosed with Bipolar disorder which is caused by my immune disregulation, probably Lupus.
https://apm.amegroups.com/article/view/60122/html
Anyway, it is difficult for the doctors to get medicare to cover these tests. I also insisted she perform a serum amino acid test which revealed several high amino acids including all of the branched chain amino acids. She had to make up reasons to get them to cover the tests even though I have all these issues, including poor kidney function.
There is defiantly a stigma with how they treat people with mood disorders. Any physical complaint was always treated as it it were something I was imagining. I was only luckyy that my mother and brother has Ankylosing Spondylitis because even though I still had to fight to get an MRI for my lower back pain and they found I was in the early stages of the disease as well.
She said now that she had the nutritional results she did not know what to do with them and she could not even send me to a specialist.
So were they hesitant to do the test at all, or was it that they didn't know how to order it for your insurance to cover it? That would be a big difference in my mind. Most doctors don't fight having blood tests done if there's at least some rationale for why to do it. They're so common and low risk.
Yeah, I have had doctors just totally dismiss things when they know nothing about them (like saying things that are unsupported and contrary to new research). I have also had doctors say they didn't know but would do some research (good sign, but less common).
But all this too extensive logging, research, and persuasion on my part.
To emphasize the issue I have had with doctors on medicare; I had IBS-D, a flare up so bad, for over a month. I went to a doctor, they took one fecal test which showed nothing. They did not reply to my continuing issue so I went back to them. The doctor said exactly this; "What do you want me to do about it?" I lost it. Yelled at him so loudly others came into the office. They never sent me to a gastro doc. I need up curing it on my own by using my understanding of my genetics and diet changes.
First resort for T2 diabetes. T1 diabetics have to go on insulin immediately, there's no other option.
https://www.aacc.org/science-and-research/scientific-shorts/...
https://link.springer.com/article/10.1186/s40199-015-0127-4
https://www.cambridge.org/core/journals/nutrition-research-r...
https://www.e-cep.org/journal/view.php?number=20125555368
I believe that Type 1, being classified and "autoimmune disease", can be reversed.
Doctors know that if they compared "taking Metformin" to "eating a low-carb diet," the low-carb diet would win hands down. But that's not the comparison that's relevant for them, because it's not a choice they get to make. They have to choose between "advising someone to take Metformin" and "advising someone to eat a low-carb diet." The results of the latter are negligible on average.
It's quite practical to do both.
Also, if you stress the dietary approach too much, a lot of patients will eventually ask, "If I make the dietary changes, is it possible I can avoid taking medication?" and you have to say "yes" and now the odds are you'll never see them again and they won't get either. So you mention the dietary changes, just so they know it's effective if they're inclined to go that route, but you focus on getting them to take medication.
It's definitely a sad compromise aimed at the average patient, and doctors hate it.
That said in this case the 40% is genuinely scary, because it's a jump from 3.3% with birth defects to 5.2%, or in other words nearly 1 in 50 babies (1.9% of births) standing to be affected by this issue. Although just quickly skimming their numbers, the sample size is unclear to me. That jump was driven by only 13 birth defects among those taking the drug, based on what the article says is a sample of 1.1 million births.
What the hell… that has to be a mistake? What is going on? Can poor lifestyle really cause this massive increase in young people with diabetes??
It's basically "oh, your blood sugar might be an issue, let's start with metformin" where in the past it was "lets try a bunch of others things and just watch your levels for a bit"
Type 1 is incurable.
My point is that the psychology of eating is so strong that people would rather take a drug that pass on birth defects to the future than change eating habits.
And I’m a person coming from struggling with just those habits. I think if someone could come up with a treatment to adjust mindsets - it would change healthcare forever and end the need for drugs like Metaform.
Of course there could be irreversible damage to those organs and that would be really bad (Several relatives who died of this).
But you are partly right. There can be remission and back to normal with lifestyle changes and Type 2. Substantial studies and clinical evidence shows this.
This is such a weird thing to say. If it never comes back you cured it. It's like saying a cold or cancer cannot be cured, but it can be put into permanent remission.
It likely takes the agency away from people and apologizes for the failures of the medical industry.
This is not a failure of the medical industry and no apology is needed.
> if the intervention is removed then the condition will return.
If the interventions preventing covid are removed the condition will return. Do you get that?
On cancer; we all have malignant cells, all the time. everyone right now has cancer cells in their body.
https://news.cancerresearchuk.org/2018/04/18/science-surgery...
Not smoking is an intervention against getting "too much" cancer.
> While a low-carb diet can often put type-2 diabetes into remission, if the intervention is removed then the condition will return
Low carb diets do not cure diabetes. They treats diabetes. The cure to diabetes (type 2) is not engaging in a lifestyle that causes diabetes, which probably results from causing a zinc deficiency.
You can avoid diabetes like you can avoid COVID.
https://www.medpagetoday.com/opinion/vinay-prasad/94646
Good lifestyle choices can usually prevent type-2 diabetes, but prevention is different from curing an existing condition. That's just medical reality and changing terminology wouldn't impact that.
The zinc deficiency hypothesis is interesting but remains unproven, and can't possibly explain large increases in diabetes. This would be a good area for further research.
Just be clear, if the hypothesis was proven it would not be a hypothesis anymore, but would be a theory.
> can't possibly explain large increases in diabetes
You cannot say it is not possible when there is so much evidence that it is possible. Tell me how many people you know diagnosed with diabetes have their doctor get their serum and urinary zinc tested?
https://www.sciencedirect.com/science/article/abs/pii/000293...
"Twenty-five percent of these patients had depressed serum zinc concentrations, and all demonstrated hyperzincurla."
100% had high urinary zinc. 100%. This point to a functional deficiency of zinc. 25% had a true deficiency. It might be that the levels of zinc that we have deemed adequate are not adequate for all people.
and this is a great short peice: https://www.proquest.com/openview/4aaebeab5e4ac98c2d1c3ced49...
The time for research is over, it is time to include serum and urinary zinc testing part of the standard of care for physicians.
And who will pay for this research on a low cost option to reverse diabetes when so much money is to be made on new medications>
> Most people including me don't engage in daily ongoing interventions to avoid COVID-19.
Same could be said for cancer and diabetes. You are probably unknowingly intervening against disease. As far as COVID, you will note the obese are more likely to suffer worse outcomes. So for whatever reason someone watches their weight, even vanity, they are helping prevent themselves from COVID.
> prevention is different from curing an existing condition
My mother prevented her self from having the symptoms of having the symptoms of diabetes occur again by changing her diet. How is that different from curing it?
Listen, what is a disease but a collection of symptoms? If I have no symptoms, where is the disease? If I had diabetes, but was never diagnosed, and I treated myself with a diet to make it go away, would a doctor diagnose diabetes when my blood sugar was normal? Funny, it sounds like you are saying doctors causes permanent diseases?
Everything we do around the topic of obesity is about palliative care for people's feelings. Health At Every Size, societal disdain for fat-shaming, etc. Medicating people with statins and insulin management drugs instead of directing them to put down the fucking fork and move occasionally.
Hundreds of thousands of Americans eat themselves to death every year. It is far and away the leading cause of early death, with COVID years additionally highlighting the fact that the VAST majority of deaths under the age of 60 were among the cohort who think donuts and beer constitute an appropriate dinner.
But instead of trying to save these people's lives, we are trying to spare their precious feelings, with the insane irony of the situation being that obesity itself is a STRONG predictor of depression. As if telling people that chugging a case of Pepsi per day is totally fine because you're beautiful as you are is going to save their mental health from the vagaries of the practically inevitable Zoloft drip they'll need to be on to keep the 9mm out of their mouth.
> and apologizes for the failures of the medical industry.
Our culture around obesity is absolutely batshit insane. And yes, medicalizing the symptoms rather than public hangings for food industry executives and widespread re-adoption of fat shaming is a HUGE factor in this.
edit: Sorry to be somewhat animated about this topic, but I am a former fatass who was, like many many Americans, victimized by the food and advertising industries, and eventually came to hate myself enough to strip off the fat and keep it off for well over a decade. And my "negative self talk" has led to being a MUCH happier person. It drives me INSANE that this culture is killing so many of us and wrecking our mental health, but we choose to make it worse.
And yes, obesity, fat cells are immune cells and they are inflammatory under a poor diet. And this ignorance of the nature of obesity is even more important with SARS2 running around rampant.
I will only say that obesity combined with nutrient deficiency is more important than obesity alone.
https://www.nature.com/articles/d42859-021-00051-w In a healthy body, adipose tissue plays a positive role, serving as reservoir of energy in times of food scarcity. Fat tissue is also full of immune system cells. And in lean, healthy individuals, it secretes factors that are anti-inflammatory and protective.
If, however, the fat tissue becomes unhealthy, as often happens in people with obesity, it can become dysfunctional and secrete hormones and other chemical signals that promote chronic low-grade inflammation.
I have no idea why people keep saying this.
The pancreas insulin output is low that's type II diabetes. From my understanding the pancreas, an organ, is damaged and can't regenerate like all organs except the liver (sort of). Like a rotten tooth can't regrow an organ once damaged there's no repair. Pancreatitis is what I'd see as a reversible situation since it's inflammation of the pancreas but not damaged yet.
Coca-cola successfully got entire nations to change from their traditional drinks to soda pop using propaganda.
I think we need to deal with the American Oligarchs/Megacorps in a very serious manner and very soon.
- find areas that aren’t medically serious (speaking relatively, and in relation to life threatening - erectile dysfunction and male pattern baldness)
- run people through online questionnaires
- get an online subscription runner stamped by a doc on their payroll
- send out generic medications that they get cheap, package them nicely, and make bank on markup
- catch them on the next condition they roll along to
The last year I’ve seen a lot of them shifting into metformin (after finasteride and viagra/cialis) for weight loss
So here is where it gets interesting with the VC-backed Subscription healthcare model. I did a touch of consulting for one starting in Australia (well, it would probably be a stretch to call it consulting but I sat down with the founders as they were running through their spin-up process).
My concerns are that you can't just prescribe anything to anyone, and for the vast majority of prescription medications there are often side-effects that need to be monitored (some of which can be serious), as well as inappropriate prescribing. The 2 examples the company I was talking to were Finasteride as well as Viagra. Seperating these two out, my concerns with Erectile Dysfunction are that it could be inappropriately funnelling everyone into prescription treatment, when there is in a reasonable percentage of cases other psychological issues that are impinging on erectile function, and whilst it might be all well and good to get viagra to get to the end result, it is also missing the broader holistic picture of aiming to achieve better health.
For finasteride, there are a reasonable percentage of people who experience quite unwanted side-effects, from gynaecomastia to erectile dysfunction. Since the target audience is young men, these effects are often more psychologically concerning than the cosmetic issue they were trying to solve with a serious prescription medication and I was concerned about follow-up, referral and support in these instances.
I was able to be reassured by them that they had adequate safeguards in place and good clinical governance oversight to achieve good all round care and then we split ways. I have no idea if they have or are maintaining those protections; additionally I have recently heard they have been pulled infront of the regulators here in Australia for cutting a few corners so my suspicion is that the money and growth hacking has gotten the better of their product development.
Ultimately it is going to be an interesting bounce between both the regulation and the inevitable clinical disasters that will pop up. There's no doubt there is room for innovation in the space, and I feel that there is certainly a way to do it safely - ensure that, for certain conditions, you can answer a few questions, get your medication, and still have safe follow-up, and do this in a innovative way that reduces overall demands on a healthcare professional for a full sit-down (ie wrap up a bunch of the bullshit in algorithms and decision trees and take care of a lot of the back room stuff).
But after 9 years as a doctor and a health-tech founder, I am also convinced that there are a number of elements of health that just do not scale, at least not with anything like the technology we currently have (ie well developed expert systems - I am also fairly fundamentally convinced that the use of AI for diagnosis and the black-box internals is going to cause issues due to uncertainty over where the fuzzy edge lies)
So - TLDR: do I see VC driven subscription prescription as a bad thing? No, but also potentially yes
I must be living in Utopia then, I thought it was Norway! :-)
When I run out of my blood pressure pills I can spend a couple of minutes online to send a message to my doctor. He spends a few seconds online to renew my prescription and then I can go to any pharmacy to pick up three months of pills. For the rest of the year I just go to a pharmacy to pick up a repeat when I run out.
Getting to your point of "other psychological issues" that can result in ED. Cialis and Viagra are there for one specific case of ED, which isn't caused psychologically. If you can get an erection in the morning, while you're sleeping, PDE5 inhibitors won't help.
Of course, the less drugs you take, the better, easier on your kidneys and liver. No drugs are without side effects, PDE5 inhibitors have them, but they are mild and can be diagnosed easily. Of course, dose is important, and health issue history needs to be taken into consideration.
Did you mean to say can’t?
I think it’s probably more of a spectrum and not a binary thing, and so you can have layers of physiological and psychological impediments, and one could also feed the other.
Did they look for any defect correlated with any drug? Because if they did, random chance alone would find something.
Anyone read the actual study?
P-values seem to be carefully hidden (not in the tables) and as far I could tell were not passing FDR. A lot of models were displayed in various tables and very few of them even had OR CIs that didn't overlap 1.
Maybe don't take it before trying to get pregnant. Also maybe this needs to get confirmed in larger studies and in other countries.
In nearly all cases, T2 is preventable. That is, unlike T1, there are things an individual can do to not reach T2.
There are also subgroup susceptibilities in play: Asians and people with Hispanic backgrounds are disproportionately represented among American T2 diabetics[1]. Recent studies suggest these groups are actually underdiagnosed still, since the dominant T2 tests are less reliable on them[2].
[1]: https://www.cdc.gov/diabetes/library/socialmedia/infographic...
[2]: https://jamanetwork.com/journals/jama/fullarticle/2757817?gu...
https://www.ted.com/talks/ron_finley_a_guerrilla_gardener_in...
That can't possibly be right. What am I missing?
To begin I would like to share that I was born with an undecended testicle (cryptorchidism) that had to be removed surgically when I was 3. My brother was born with hypospadia. I have been studying the genetics and environmental issues around these for the last 15 years.
I carry several high risk genes for diabetes but probably the most relevant is that I carry the homozygous risk alleles for rs2466293 in SLC30A8 which is a zinc transporters gene. So I absorb zinc more slowly than most people.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428214/
"Conclusion ZnT8A detection increases T1D diagnosis rate even in mixed populations. SLC30A8 rs2466293 was associated with T1D predisposition in non-European descents."
I had my serum zinc tested and it was low. So now I need to take 240mg of Zinc Sulphate and eat a lot of oysters to keep my zinc levels up.
I was diagnosed with Lupus and now I no longer present constant symptoms.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544280/
"Ikaros family zinc finger 1(IKZF1) encodes a lymphoid-restricted zinc finger transcription factor named Ikaros that regulates lymphocyte differentiation and proliferation as well as self-tolerance. Increasing evidence indicates that IKZF1 could contribute to the pathogenesis of autoimmune diseases."
So also understand that my mother had diabetes, an immune disorder, and a mood disorder, all of them linked to zinc deficiency.
So, in studies zinc deficiency has been linked to diabetes:
"Zinc deficiency is a risk factor for obesity and diabetes."
And genital abnormalities: (This is just one study, but there are hundreds like it.)
https://www.karger.com/Article/Fulltext/441988
"WT1 is a transcriptional regulator with various functions including signalling in both the embryonic kidneys and gonads. Mutations in this zinc finger transcription factor are associated with Denys-Drash or Frasier syndromes, which result in a broad range of malformations including hypospadias."
So I do not think the problem is metformin. I think the problem is doctors not providing patients with diabetes a full nutritional workup and ignoring the role of nutrition in human health.