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I've never used it, but I guarantee that Proxmox can pass through PCIe devices with VFIO, and USB requires no hardware support at all.

vmkernel hardware passthrough has exactly the same requirements (IOMMU support).

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My statement was vague, apologies. I meant client-side pass through of devices. (such as plugging a USB device into your client, and the remote VM believing it is local)

SPICE on Proxmox may support this but I find it incredibly clumsy to configure.

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