Genuine question: how does someone in her position know they're right and the research is wrong, and not the reverse?
I'm certainly not denying that she may be correct, and I'm not unquestioningly defending research evidence either.
We've come a long way from "eminence-based medicine", where the senior clinician was impossible to challenge. Research has helped us move towards a more nuanced approach to care (I would say "holistic" but that word has become tarnished).
EBM "phase one" alienated clinicians despite explicitly acknowledging clinician expertise, by overemphasizing evidence and undervaluing experience. EBM "phase two" aims to redress the balance, but perhaps the mistrust is too significant now. It would be a shame if so.
Some reading:
https://www.bmj.com/content/348/bmj.g3725
https://www.cebm.ox.ac.uk/news/views/it-is-time-for-evidence...
And that's the rub. Most people who try to improve the system reinvent it with the same or worse flaws. You'll notice for all the hand wringing and complaining here about how flawed the process is, no one really has put forth a suggestion on how to fix it. A lot of people here are not even part of the process and looking in from the outside, so they don't even understand the incentives involved enough to fix it. Hence the endless complaining...
This is where you pull out the rusty ol' tools of Figuring Things Out From Evidence, which mostly boil down to:
come up with your own theories and listen to theories from others
think really hard about which one explains historical evidence the most consistently.
think about experiments to make sure theories aren't overfit to historical evidence
conduct those experiments, and "penalize" theories which don't explain the experimental results
these tools are strange things because they (noisily, but surprisingly reliably when applied truly honestly and openly) predict which theories are predictive of future experimental results.
and that's all you want out of a theory, really.
if she says, though, "actually, I'm right and the science is wrong though, and here's why:"
and explains her entire process, what results she's seen hands-on in her own surgeries, and is careful to also include anything she saw that isn't consistent with her theory..., shows her reasoning, and shows her work... that's convincing and persuasive. It's also not easy, and requires lots of work. So does figuring out things in general.
And that's called "an argument".
(Paraphrasing Karl Popper, mentioned in the article).
What epistemological techniques do you use to distinguish intervention A from intervention B and how do you distinguish your experience from the paper that shows the opposite result?
The number of variables are large: including, distressingly, your skill at technique A and technique B. Is the difference in the outcome merely your lack of skill in one? Is the difference merely the lack of skill of the guys observed by the paper?
My parents are also experienced surgeons and the normalizing method they use is to share their findings with fellow surgeons. Patients where they work are much more amenable to having photographs of their surgeries used as discussion material.
Medical science is a primitive science and it is practised with primitive statistics, so most evidence is just missing. Lots of surgical techniques are discussed based on too little evidence with massive true error bars.
No, that's wrong. There are several reasons why a negative result doesn't necessarily disprove a theory or a hypothesis: measurement uncertainties/noise, experimental errors, software bugs, bit flips, ...
The experimentalist world is messy and full of hidden dependencies.
(And to be fair it's usually the people with less experimental experience that take him the most seriously)
Clinicians I know who get frustrated with academic research that draws conclusions about clinical work are criticising papers that are more like this:
(I’m exaggerating for effect, but not exaggerating a lot)
“People think this clinical technique is effective. But when some academics with very little clinical experience performed a rough approximation of the technique, in the wrong area, with the wrong tools, in the wrong way, on a small number of randomly chosen patients, they found it performed no better than placebo. Therefore no one should use that technique on any patient.”
Poor doesn't begin to describe it.
The reason the majority of people end up with higher degrees and the jobs that require them has more to do with wealth/class and social privilege than actual competence or intelligence. It's almost to the point where people who are actually good at something end up with an appropriate line of work almost by coincidence.
That's the natural outcome when you organize your society by wealth instead of skill.
She doesn't know, and that's the problem with medical research: being a specialized surgeon is like a carpenter who's made hundreds of a particular kind of furniture. Then a scientist comes along, saying we should change how we do it. As an experienced carpenter, you know that most of those scientists actually have very little practical experience, because they used that time to publish and are actually very bad, practically speaking. And therefore oftentimes reach nonsensical conclusions. So, what to do? You go ask the most practically experienced guy you can find, hoping he'll be able to guide you. Repeat 100x/year.
I'm not exaggerating: some of our academic practitioners who've published a lot are really among the worst practitioners I know, and do kill people who should have lived on a regular basis! Ironically, some of them are respected professors and patients often seek their care thinking it'll be better. One of them is a surgeon and has received an award for outstanding teaching. He's the absolute worst surgeon I know.
So, no easy conclusion here...
That doesn’t sound like science. An example or pointer would be helpful.
What do we do now? The exact opposite, and much closer to usual ARDS practices. You can argue that wasn't a mistake because it followed the process of scientific discovery, but it's nevertheless a tragic example of experience trumping the advice of the scientific community.
That's really not what I meant. I have no problem with the publication. But put yourself in the shoes of someone such as myself, who's intubated tens of cases on admission and probably killed many doing so. Wouldn't you be questioning the structure of our research system then? Not that I have any better solution at hand, mind you...
This is what I don't get. Science is contradicted and questioned all the time. It's the main mechanism by which science evolves.
Also a crucial feature of science is that it's literally always wrong. Science is the iterative process of building models of reality, and those models by virtue of being models never 100% represent reality. Scientists understand this and are always working to improve our knowledge by further refining our models.
Why do you feel like science is not to be questioned? Moreover, if you're dissatisfied as a practitioner with scientific review, why don't you get involved more with the review process? In my field practitioners publish and are involved with our research and peer review all the time, is this not true for your field? Can you work to change it?
In my experience if you don't agree with published research, you don't just lay down and accept it, you do your own research to counter it, and publish that with a big fat citation of the old paper saying they're wrong. Where does this idea come from that science is proclaimed from on high? If you don't like it, roll up your sleeves and prove them wrong -- science is done from the bottom-up.
At the same time though, I get it and I do this too. This might be too reductionist but I think most of it comes down to trust. It's very expensive, in terms of time, to have a critical understanding of any specialized field. So taking the shortcuts like past experience, intuition, relying on others are more profitable. Especially if the goal is survival and not understanding of a system. This then becomes a game of finding the most "trustable" person but that's the catch 22.
I don't know who came up with this notion that science is high-minded (probably a scientist) but it's really as petty as any human social process. Go back through history and you'll note plenty of scientists persecuting some other group because they're challenging the orthodoxy. If that makes you uncomfortable maybe science isn't for you, but that's the truth of how it's always worked (and always will work unless you can solve the human angle of this).
Most ideas, especially scientific ones, are almost never accepted on their own merits. They have to be forcefully pushed on the world, and that ruffles some feathers, because that means crowding out some other competing idea. Remember we call this a "marketplace" of ideas. Not everyone comes home from the market happy.
I guess my bottom line is: welcome to how the sausage is made. During Covid some people got a look and found out that they don't like it, shocker. The good news is you're allowed (no one is stopping you) to participate in the process with your own ideas. You just have to steel yourself against criticism and inoculate yourself against the inevitable retaliation and pushback. If you believe in your ideas, don't give in!
So to be able to (at first) produce tractors and later switch that to tanks he sold his people to the US that knowingly and gladly accepted the cheap food.
So both nation's political and industrial leaders are responsible for the mass starvations. One can't just blame it on Stalin or on Lysenko.
But Lysenko might have made the problem even worse. That much we can agree on.
Source for further reading: https://twitter.com/kamilkazani/status/1505247886908424195
The US’ raison d’être is (hopefully) not knowingly starving millions of people to death. When you’re making a deal of that size (between countries, not a company and consumer) no deal is purely transactional, there are ramifications.
Not that any other country would have acted differently. I am not here to metaphorically shit in the yard of the US. It is just business as usual when it comes to politics. Sadly. I just don't expect people to act with integrity when in positions of power. I still like to be pleasantly surprised if it happens - I just don't expect it.
Edit: Typo
Of course the US is complicit (just not solely complicit as you imply I claimed - nice rhetorical figure by the way just a bit too obviously applied). They knowingly let a dictator pay them in natural resources while these resources were lacking for the people and this lead to famine and mass starvation.
So to stay in your image: When Remington sells me a shotgun knowing I will go and use it to kill my family (because it was clearly visible) they are complicit.
If the US would not have know the consequences of their deal with Stalin for the ordinary people we would be talking about a different situation here. But the US knew. And they still took the grain and other resources. And that makes them complicit.
In my world, that makes the U.S. very clearly an accomplice to a dictator who is starving his people. And also profiteers from such a system.
But hey as if this were something new or shocking. I don't know about US educational system, but i thought it was public knowledge, that the US acted that way as their standard modus operandi for many decades now.
No matter if with South American dictators, with African dictators or even with dictatorial regimes in the Middle East, as long as they do not become too rebellious and do not challenge the supremacy of the USA the US are willing to trade and not look too closely towards the crimes against humanity these dictators are performing.
Take Saddam Hussein as an example.
Wasn't it the U.S. that continued to financially and militarily support Saddam Hussein in the Iraq-Iran war even after he openly used chemical weapons? Without the U.S., Saddam would never have become head of state in the late 1970s. And the US gladly bought his oil - ignoring what he did.
This is the same as we Germans are currently also responsible (at least in part) for the prolongation of the war in Ukraine, because we still do not want to give up the gas supply from Russia. We are prolonging the war because our money is helping to finance Putin's military advance.
Our convenience and the intransigence of our government makes us complicit in the death of many civilians.
No, that's a very different metaphor.
The item being bought causes no harm. The problem is reckless spending. That puts the bar of responsibility in a very different place.
The US was probably a net grain exporter at the time, so I think you are not presenting the situation very well. There is certainly complicity in working with an oppressive government that is starving its people, but saying it was done for "cheap food" when USSR was selling the food elsewhere and paying in dollars isn't the right way to present it.
So he sold the grain that would feed his people in exchange for USD, Deutschmarks, Pound Sterling that he could use to buy industrial equipment.
I mean, it's not exactly out of place for Stalin to sacrifice his people's lives to realize his goals for Mother Russia. Plus the added benefit that the people dying were troublemakers anyways (Ukrainian nationalists).
Do note that when the famine did strike, those same foreign countries offered famine relief that Stalin promptly turned down.
had to or chose to?
It's an interesting thread, thanks for the link, but "knowingly and gladly" is not supported there, I don't see how you can lay any responsibility for Holodomor at Henry Ford's feet.
As you can imagine this takes time and money and all of it is sponsored by a not for profit EQA organisation, with no pharma companies involved (since they're who provide the tests and that's a massive conflict of interest). As a result the org only manages to produce two or three guidelines a year, when really they'd like to be able to produce a dozen or more. And they also need to be reviewed at regular intervals which while slightly less long winded is still long winded. Really this is the sort of thing that is a prime candidate for being sponsored by government, and sometimes it is, but since these are rare conditions the cost / benefit analysis is not always favourable.
I used to think "well med school is really hard, so the bare minimum for a doctor is pretty good". Then I started working in healthcare and realize, no, that's not true at all.
The best example I can think of is when I worked on a project where we wanted to get ready for a much better competitor in a disease area. Not "slightly better", but "mind blowing better and not using it would be malpractice". Most doctors had heard of it, but we want to remind them not to purchase the company's older drug because they'll just return it a year later.
Turns out there were multiple doctors, after the new drug was approved and available, that continued to use the old drug. We literally had to go to them and say "hey stop buying the company's drug please". And I realized, damn, these doctors' patients are getting really shitty treatment.
If a new cancer drug was launched that could help would you prefer a doctor that said “sorry, the next guidelines update is in 9 months, so I’m not using that drug”?
It might even be that you don't have to be an experienced clinician to tell something is wrong, but an experienced clinician would pick up on the problems immediately just through familiarity.
Feynman used the term "cargo cult science" and in my experience it applies to EBM more than any other area I've encountered.
> academic doctors HAVE to publish in order to advance their careers
Indeed. But the issue is what criteria will you use for promotion if not that? Don't even think of evaluating clinical results, that's even worse than what we have.
> This happens even at the best centers
This happens ESPECIALLY at the best centers. Because centers are in good part ranked according to citation counts.
> I don't know what the solution is, but I do know that whenever she has needed treatment for herself she generally ignores most of the research and talks to the most experienced surgeon she can find.
After 10+ years in the system, I'm in the same boat. And although I've given it a good thought, I don't see a solution either.
This incentive structure distorts research. What to do about it? I'm not exactly sure but having university administrations who see research as a means to make money, rather than an end in itself, is not the way.
Putting safeguards in place is a good thing. It’s like traffic rules that people need to adhere to.
(They are very useful tools, but like very tool, not the solution to every problem.)
A lot of the reasons of this distortion is due to the lack of funding from government in state universities which keeps going down as the cost of running a university keeps going up. Because of the rising costs, things get pushed to extremes and the accountants/administrators are put between a rock and a hard place.
Depending on the university in question, it might not be just about "making money" but just not shutting the university down and trying to swim upstream in a never-ending battle.
More fundamentally, I think the US really needs to step back to the basics and think about different ways research can be funded, and to what extent current funding systems map onto those different mechanisms. I think there's a lot of dishonesty about what is going on, in terms of how research is funded in theory versus what actual expectations or practices are, and what the consequences of all of it is.
I also know of a couple of chemistry professors and one is new and his PhD was overseas in Saudi Arabia and he basically said it was just large scale brute force data analysis and discovery of chemicals in Python with a small amount of lab work to prepare the datasets. Basically there's a huge pipeline for this sort of work to discover new chemicals in labs, get a PhD out of it, but it's all just sort of an engine that functions to brute force the chemical possibilities not real meaningful research. I never asked but I assume the results just get fed into a pharma company or something.
Then you have those chemists on the opposite end, ready to retire, who are working on cold fusion because why not it's interesting to study even if it goes nowhere.
Our whole society has kind of turned into a giant web of a machine that can't be untangled without ripping everything apart. Some of it is stupider than others, but most of it is kind of a bullshit layer on top of a bullshit layer. We obviously see that in IT as well, with marketing tools that are just wrappers for simple underlying tech that anyone could set up. Sometimes there is significant value added, sometimes there is none (or even negative value).
I don't know where I'm going with this so I'm going to stop typing.
https://nces.ed.gov/programs/digest/d20/tables/dt20_334.10.a...
Expenditure per full-time-equivalent student in constant 2019-20 dollars is up about 10% over a decade in the instructional and student services categories. That's not that much. (The total number is going up, driven by costs in hospital services, mostly)
Really.
Dice roll? Alphabetical order? If it's gonna be arbitrary or close-to, it would be preferable for everyone if it didn't erode science as a side effect.
Every PhD knows how to read literature. But throw them outside their narrow line of expertise, and they will not be able to tell apart a good from a bad paper. It's the same reason you cannot trust your FB Karen who found a publication that supports her conspiracy theory.
So yes your wife is right in looking for the most experienced person in the field for an opinion.
When I was in elementary school, I saw the same thing. People forced to write essays on things they were not necessarily good at, just in order to advance to the next year. The result, of course, was a crapton of half-assed essays, many of which were bullshitted together not long before the deadline. I sincerely doubt even half of them where in any way useful whatsoever.
At least in my school, few people improved their essay skills over time. Maybe they learned more technically impressive ways to bullshit, but their writing did not improve. (Some people's writing improved, but often they turned out to be writing things on their own interest in their spare time.)
I know at the time I said to myself, "This is dumb, but it's just school. It's not like this for adults, of course. They have their shit together."
Turns out many adults still do that!
This is bad on so many levels it's bordering on unintentional evil. Someone should start a revolution.
Then at some point it dawns that it's just clowns from bottom to top.
I'm starting to suspect it speaks to the adaptability of people.
Formality not content ruled.
(I just hope other places/institutions/fields do it better)
It turns out, being genuinely interested in something when there is zero money to be made is a much better predictor of success than having formal training and insider status.
* sorry Golang people and anyone offended by this it’s just an example
Luckily the IT industry can just ignore them and demonstrate something better without bothering 6 other organs to check if they are allowed to build it.
But in truth i'm starting to worry about the Hollywood-NSA-Savethechildren 'consultants' influence on the laws that panders 'technical' solutions to make general computation a service instead of a human right.