Take a substance like chlorine. It is put into municipal drinking water because it kills things - things that can kill us or harm us. It is credited with making municipal water a lot safer.
It has been shown to be safe and effective for most people.
The key is most people. Some people, at the edges of the bell curve, cannot tolerate chlorine. If they drink water with it, or bathe in water with it, it harms them. I have family members who have this sensitivity. Since moving to a place with well water, their health has improved immensely.
If you were to be guided only by studies that show the safety and effectiveness of the chlorine treatment, then you could overlook the fact that some people are outliers.
Evidence based medicine will guide you to things that will work for most people in a given situation. However, for a specific patient, you may need to depart from that evidence.
Limiting doctors to only evidence based approaches prevents them from treating specific patients.