If you’re into the pharma business you should consider Boston, San Diego or sf. There’s some other areas, but you have to be able to switch jobs without moving unless you’re a renter. If your politics doesn’t require the us, look into Vancouver or Toronto. Yanks file taxes each year so there’s little issue in Canada. Dealing with logical regs would be more hassle without a local nexus, but many places have one.

A lot comes down to your comfort in the various areas of the us. No need going somewhere you’ll be uncomfortable with.