The relevant agency would be the FTC, but is the FTC even interested in pursuing these cases? I've seen a few cases where they sued scammy businesses (https://www.ftc.gov/news-events/news/press-releases/2019/12/...), but there are lots of legitimate businesses that are nonetheless breaking the law. For example Xfinity sent me an ad for a voice-activated remote, categorized it as a "service-related email" and had no unsubscribe link. Instantly marked as spam.
What I want to know is: has there ever been even a single case of the FTC going after one of these real companies?