Absolutely.

The Regolith website puts the full iso front and center (for some reason), but you can also just add the PPA and install one of the `regolith-desktop-*` packages - mostly config with dependencies on gnome, i3, and picom. It easy to drop back to vanilla ubu/gnome when the project goes stale or you find something that doesn't play nicely with tiling WM like Unity editor.