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3 monitors is absolutely the sweet spot. On my MBP I use 2 USB display adapters and shut the lid to give me 3 external monitors running, works really well for a number of workflows. To main screen setups I find most useful are Web Dev: Web Page - Code - Documentation/Google/command line and TDD: Test Code - Code under test - test runner

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What's the latency like with USB display adapters?

I've been running a triple-head setup for years, which is one of the reasons I've never been able to use my MBP as my primary machine.

under Windows they perform really well, no noticeable difference between them and the main screen, on OSX they aren't quite as good in certain applications because their drivers aren't as solid for OpenGL but I barely notice it

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