Ubuntu 22.04 (Jammy Jellyfish) won't be released until 2022-04-21, so it's not officially supported right now. That means it's considered off-topic for sites like AskUbuntu.com, for example, so if you want assistance with any problems you encounter you're probably better off waiting a few months.
As for what's different: you can read the current draft of the release notes for 22.04 [1] as well as the release notes[2] and official blog post[3] for 20.04. One big change from 18.04 is Wayland by default, another is optional ZFS support.
Also keep an eye out for removed packages you might care about so you can plan workarounds or replacements. For example, the music players Amarok and Banshee are no longer available after 18.04, nor is anything that didn't make the Python 2 to Python 3 transition. There are also new packages, or newly re-introduced packages like OpenSCAD and pdftk (although these are also available on 18.04 as a snap).
When you do upgrade, consider installing onto a new blank disk and then transferring your files from the old disk afterwards. I have used this approach exclusively after experiencing one-too-many bugs that originated from old system-level configuration files. It also means I have a fall-back drive if something goes wrong during installation.
[1] https://discourse.ubuntu.com/t/jammy-jellyfish-release-notes...
[2] https://wiki.ubuntu.com/FocalFossa/ReleaseNotes
[3] https://ubuntu.com/blog/whats-new-in-ubuntu-desktop-20-04-lt...