Welcome to the wonderful world of everyone whose countries native layout doesn't have a dedicated key for /, like most of europe.
For example I can't do Ctrl + ] because I need AltGr to produce ] and that won't work with Ctrl. Also I cant do Ctrl + ` because ` is dead key for me (it appears only after I type space or any other character).
On a Mac, you can use ⌘ keys as QWERTY, but have Dvorak for everything else. Like the other comment, this sounds like someone who hasn't given an alternative keyboard layout a serious try.
I'm typing on neo [0] and it's no problem at all.
As a Dvorak user on macOS for ~12 years, I do believe it's an issue. I use "Dvorak - QWERTY ⌘" as my daily driver and while it works for most applications, it's infuriating for those it doesn't. Sometimes keyboard shortcuts are control/option based without using command, so it's still in Dvorak mode.
In Gimp, the New Image shortcut is ⌘-N, which doesn't work. I have to press physical L, which is the key for N in Dvorak. This is common. The apps seem to do some lower-level key detection. https://gitlab.gnome.org/GNOME/gimp/-/issues/3352 I think Fusion 360 does similar, though I don't have it installed at the moment. I have also had trouble with remove desktop applications, which is kind of to be expected but another downside.
When the layout is at the hardware level, the OS only ever sees the actual keycode for the N key, instead of an "L" which is later transcribed into "N" by the OS's layout map.
It is problem both for MacOS and Windows, my examples will be for Windows, but MacOS has exactly the same problem.
Imagine, you have two keyboard layouts installed: English (standard one, QWERTY) and Russian (standard one, ЙЦУКЕН, but it doesn't matter).
Typical shortcut for "Open File" is Ctrl+O (O is English O). This key in QWERTY is on top row, on the right part of keyboard. Russian layout has letter Щ on same key. You can press Ctrl+O when English layout is active or you can press Ctrl+Щ when Russian layout is active, it will work the same: activate Ctrl+O shortcut, and shows you "Open File" dialog.
Now Imagine you have combination of English Dvorak layout and same Russian ЙЦУКЕН layout.
Open File shortcut now uses DIFFERENT KEYS in DIFFERENT LAYOUTS. When Dvorak is active you need to press Ctrl+O, where "O" is in the middle row, on the left. This key is Russian "Ы" in ЙЦУКЕН layout. Sounds good so far. But when Russian layout is active you need to press... Can you guess? No, not Ctrl+Ы (where Russian "Ы" in ЙЦУКЕН is same key as English "O" in Dvorak), but Ctrl+Щ, as if your English layout is still QWERTY.
It is sick. It makes using shortcuts almost impossible - shortcuts become dependent on current active language!
And what is worse, some programs (Google Docs is one example) refuse to use Ctrl+Ins/Shift+Ins and requires Ctrl+C and Ctrl+V for clipboard operations.
I have 16 layers of possible keys activated by thumb chords (though in practice my brain runs out of awareness of different combos far before my ~1000 unique keys). So I just dedicate a layer to this pseudo-qwerty.
Need to get around to writing that emoji layer...
In addition: I see you’re a Mac user. The kind of person willing to try this layout is probably willing to reassign all those keystrokes, which is easy (but tedious) on the Mac.
The built in Dvorak on the Mac has an option to let the keys go back to normal for CMD usage, though I prefer learning them as typable letters than physically located chords.
I experiment around with my layouts and keyboards a little bit so I am probably out of touch.